Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a protein that in humans is encoded by the MST4 gene. [5] The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20 -like kinases.

In this study, we report an unrecognized function of MST4 for EMT regulation via the MST4-AKT pathway and oncogenic potential of MST4 in breast cancer, together with its function in promoting cell growth, migration, and invasion, suggesting that MST4 may serve as a potential novel oncogene for breast cancer.

2023年10月13日 · Primary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder in which macrophages play a critical role. Mammalian sterile-20-like kinase 4 (MST4), a member of the...

2023年12月1日 · MST4, a recently recognized member of Mammalian Sterile 20-Like Kinase (MST) [1], has been appreciated to play important roles in regulating cell proliferation, apoptosis, cell polarity and migration, EMT, autophagy, and cancer metastasis.

2015年2月2日 · Here we report that germinal center kinase MST4 responded dynamically to bacterial infection and acted as a negative regulator of inflammation. We found that MST4 directly interacted with and...

2023年10月13日 · Primary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder in which macrophages play a critical role. Mammalian sterile-20-like kinase 4 (MST4), a member of the germinal-center kinase STE20 family, has been demonstrated to …

2001年10月19日 · In this study, we report the cloning and characterization of a novel human Ste20-related kinase that we designated MST4 (accession number AF231012). The 416 amino acid full-length MST4 contains...

We identified Mst4 as a novel cardiac kinase that is upregulated in cardiomyopathy-regulating cardiomyocyte growth and survival. Keywords: cardiac hypertrophy; cardiomyopathy; complex; heart failure; phosphoproteomics; signal transduction.

Neratinib has been claimed, via chemical biology assessments, to be a catalytic inhibitor of MST4 with an IC50 in the low nanomolar range; however, as noted previously and in the present studies, neratinib also rapidly reduced the total expression of MST4 via autophagy.

2024年4月3日 · Cardiac Mst4 kinase is highly enriched in heart and skeletal muscle and is significantly induced in human cardiomyopathy. Functionally, Mst4 acts as a prohypertrophic, procontractile, and prosurvival kinase likely by phosphorylating several cardiac targets along the ID, sarcomeric Z-disc, and ion channels within the cardiac dyad.