
MST4 - Wikipedia
Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a protein that in humans is encoded by the MST4 gene. [5] The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20 -like kinases.
MST4: A Potential Oncogene and Therapeutic Target in Breast …
In this study, we report an unrecognized function of MST4 for EMT regulation via the MST4-AKT pathway and oncogenic potential of MST4 in breast cancer, together with its function in promoting cell growth, migration, and invasion, suggesting that MST4 may serve as a potential novel oncogene for breast cancer.
MST4 kinase regulates immune thrombocytopenia by ... - Nature
2023年10月13日 · Primary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder in which macrophages play a critical role. Mammalian sterile-20-like kinase 4 (MST4), a member of the...
The mammalian Sterile 20-like kinase 4 (MST4) signaling in tumor ...
2023年12月1日 · MST4, a recently recognized member of Mammalian Sterile 20-Like Kinase (MST) [1], has been appreciated to play important roles in regulating cell proliferation, apoptosis, cell polarity and migration, EMT, autophagy, and cancer metastasis.
The kinase MST4 limits inflammatory responses through direct ...
2015年2月2日 · Here we report that germinal center kinase MST4 responded dynamically to bacterial infection and acted as a negative regulator of inflammation. We found that MST4 directly interacted with and...
MST4 kinase regulates immune thrombocytopenia by ... - PubMed
2023年10月13日 · Primary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder in which macrophages play a critical role. Mammalian sterile-20-like kinase 4 (MST4), a member of the germinal-center kinase STE20 family, has been demonstrated to …
MST4, a new Ste20-related kinase that mediates cell growth and ...
2001年10月19日 · In this study, we report the cloning and characterization of a novel human Ste20-related kinase that we designated MST4 (accession number AF231012). The 416 amino acid full-length MST4 contains...
Mst4, a novel cardiac STRIPAK complex-associated kinase, …
We identified Mst4 as a novel cardiac kinase that is upregulated in cardiomyopathy-regulating cardiomyocyte growth and survival. Keywords: cardiac hypertrophy; cardiomyopathy; complex; heart failure; phosphoproteomics; signal transduction.
Neratinib degrades MST4 via autophagy that reduces membrane …
Neratinib has been claimed, via chemical biology assessments, to be a catalytic inhibitor of MST4 with an IC50 in the low nanomolar range; however, as noted previously and in the present studies, neratinib also rapidly reduced the total expression of MST4 via autophagy.
Mst4, a novel cardiac STRIPAK complex–associated kinase, …
2024年4月3日 · Cardiac Mst4 kinase is highly enriched in heart and skeletal muscle and is significantly induced in human cardiomyopathy. Functionally, Mst4 acts as a prohypertrophic, procontractile, and prosurvival kinase likely by phosphorylating several cardiac targets along the ID, sarcomeric Z-disc, and ion channels within the cardiac dyad.