Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene. [5] [6]

2021年4月7日 · Mesothelin (MSLN) represents an attractive molecule for targeted cancer therapies. To identify tumors that might benefit from such therapies, tissue microarrays including 15,050 tumors from 122 different tumor types and 76 healthy organs were analyzed for MSLN expression by immunohistochemistry.

The MSLN gene is located at 16p13.3 and encodes for the MSLN mRNA. The pre-pro-mesothelin consists of a signaling peptide at the N-terminus (yellow), mature MPF (blue), furin cleavage site (red), mature mesothelin (orange), and a GPI-anchor sequence (gray).

2024年12月25日 · Complete information for MSLN gene (Protein Coding), Mesothelin, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium New to GeneCards?

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2025年3月4日 · Title: Effects of hsa-mir-145-5p on the Regulation of msln Expression in Colorectal Adenocarcinoma. Mesothelin Expression Is Not Associated with the Presence of Cancer Stem Cell Markers SOX2 and ALDH1 in Ovarian Cancer.

2020年12月1日 · Mesothelin (MSLN) is a lineage restricted cell surface protein expressed in about 30% of human cancers and high MSLN expression is associated with poor survival in several different cancers.

2019年8月23日 · Mesothelin (MSLN), a tumor-associated antigen broadly overexpressed on various malignant tumor cells, while its expression is generally limited to normal mesothelial cells, is an attractive candidate for targeted therapy.

Since its discovery in 1992, mesothelin (MSLN) has generated significant interest as a therapeutic target. A number of characteristics make it ideal for this purpose. First, it is not expressed on the parenchyma of any vital organs.

Mesothelin (MSLN) was discovered as a cell surface protein normally expressed by mesothelial cells lining the pleura, pericardium, and peritoneum . It is aberrantly expressed in a variety of cancers including mesothelioma, and ovarian, pancreatic and lung cancers .

2024年4月30日 · MSLN was a predictor of PDAC mortality, superior to conventional pathologic features as a prognostic marker [[12], [13], [14]]. Additionally, MSLN has been shown to facilitate epithelial-mesenchymal transition (EMT) in lung cancer and malignant mesothelioma [15].

2020年11月12日 · Lentivirally transduced anti-MSLN CD3ζ/CD28/TLR2 CAR-T cells were found to have superior killing capacity of MSLN-expressing human lung cancer cells compared to CD3ζ/CD28 CAR-T cells lacking TLR2 co-stimulation and to produce higher levels of IL-2, IFN-γ, and GM-CSF and similarly, the TLR2-containing CAR-T cells were able to more efficiently ...

2025年1月27日 · MSLN is a cell surface protein expressed in several cancer types, including mesothelioma (MESO), colorectal (CRC), non-small cell lung (NSCLC), ovarian (OVCA), and pancreatic (PANC) cancer, which can be associated with poor prognosis (1).

Introduction: Mesothelin (MSLN) is a tumor differentiation antigen normally restricted to the body's mesothelial surfaces, but significantly overexpressed in a broad range of solid tumors. For this reason, MSLN has emerged as an important target for the development of novel immunotherapies.

2021年3月26日 · MSLN-CAR decreased the growth of MSLN-positive tumors concomitant with significantly increased T cells and cytokine levels compared to the control group. These results indicated that modified MSLN-CAR-T cells could be a promising therapeutic approach for …

2021年7月20日 · Targeting of human MSLN + aPFs with two anti-MSLN immunotoxins killed fibroblasts engineered to express human mesothelin and reduced collagen deposition in livers of bile duct ligation (BDL)-injured mice. We provide evidence that antimesothelin-based therapy may be a strategy for treatment of parenchymal organ fibrosis.

2024年8月8日 · Mesothelin (MSLN) is a cell-surface glycoprotein expressed at low levels on normal mesothelium but overexpressed in many cancers. Mesothelin has been implicated to play role/s in cell adhesion and multiple signaling pathways.

2024年7月18日 · Mesothelin (MSLN) is a molecule expressed on the surface of various solid malignant tumor cells that is suitable as a target of tumor cells with high MSLN expression for CAR-T-cell therapy.

2019年2月18日 · Mesothelin (MSLN) has been reported to be expressed in GC tissue and could be targeted by chimeric antigen receptor (CAR) T cells. Mesothelin targeting CAR-T has been reported in mesothelioma, lung cancer, breast cancer, and pancreas cancer.

Mesothelin (Msln) expression is increased in tissue fibroblasts of damaged liver and other organs and Msln is a common mediator of liver, lung, and kidney fibrosis. We show that anti-Msln immunotoxins kill the Msln-expressing fibroblasts and reduce ...