2021年5月5日 · Mixed lineage kinase domain-like protein (MLKL) emerged as executioner of necroptosis, a RIPK3-dependent form of regulated necrosis. Cell death evasion is one of the hallmarks of cancer. Besides...

In this review, we discuss the key steps that lead to MLKL activation, possible models that explain how it becomes the death executor in necroptosis, and its emerging alternative functions.

2020年6月19日 · Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-mediated phosphorylation is thought to...

2024年12月25日 · MLKL (Mixed Lineage Kinase Domain Like Pseudokinase) is a Protein Coding gene. Diseases associated with MLKL include Maturity-Onset Diabetes Of The Young and Caspase 8 Deficiency. Among its related pathways are RIPK1-mediated regulated necrosis and Ion channel transport.

The pathophysiological actions of MLKL in the lysosome and endosome. (A) MLKL translocates to the lysosomal membrane, triggering lysosome aggregation and fusion and ultimately leading to lysosomal membrane permeabilization (LMP). The interaction between p-MLKL and BAX is also a LMP inducer. LMP may result in the release of lysosomal contents, such as CTSB for cleaving …

Analysis of MLKL expression patterns reveals that MLKL is upregulated by type I/II interferon, conditions of inflammation, and tissue injury. Overall, MLKL may affect cancer development and metastasis through necroptosis-dependent and -independent functions.

2025年2月8日 · MLKL: Functions beyond serving as the Executioner of Necroptosis. RIPK3 Activates MLKL-mediated Necroptosis and Inflammasome Signaling during Streptococcus Infection. Increased MLKL mRNA level in the PBMCs is correlated with autoantibody production, renal involvement, and SLE disease activity.

Here, I review our current understanding of how MLKL is activated by the upstream receptor interacting protein kinase (RIPK)3, the proposed mechanism (s) by which MLKL kills cells, and recently described layers of regulation that tune MLKL's killing activity.

2017年7月18日 · Activation of the pseudokinase mixed lineage kinase domain-like (MLKL) upon its phosphorylation by the protein kinase RIPK3 triggers necroptosis, a form of programmed cell death in which rupture of cellular membranes yields release of intracellular components.

2021年3月4日 · Pseudokinase mixed lineage kinase domain-like protein (MLKL) serves as a terminal-known obligate effector in the process of necroptosis. To date, the majority of research on MLKL has focused on its role in necroptosis, and the prevailing view has been that the sole function of MLKL is to mediate necroptosis.