2005年6月1日 · Scaffolding proteins organize MKK–MAPK complexes for activation by specific MKKKs and do so in specific locations in the cell. It is the MKKK associated with the …

1999年4月1日 · MKKs are characteristically dual specificity kinases which catalyze the phosphorylation of MAPKs on both tyrosine and threonine residues. The MKKs are …

2007年5月14日 · In this review, we describe how the MKKK ‘hub’ function regulates the specificity of MAPK activation, highlighting MKKKs as targets for therapeutic intervention in cancer and …

2005年6月1日 · Scaffolding proteins organize MKK–MAPK complexes for activation by specific MKKKs and do so in specific locations in the cell. It is the MKKK associated with the …

Scaffolding proteins organize MKK-MAPK complexes for activation by specific MKKKs and do so in specific locations in the cell. It is the MKKK associated with the scaffolded complex that …

signaling hubs’ that regulate the specificity of MAPK activation. In this review, we describe how the MKKK ‘hub’ function regulates the specificity of MAPK activation, highlighting MKKKs.

2007年5月14日 · Mitogen-activated protein kinases (MAPKs) are members of a dynamic protein kinase network through which diverse stimuli regulate the spatio-temporal activities of complex …

Mitogen-activated protein kinase (MAPK) signaling networks represent important means of signal transduction in plants and other eukaryotes, controlling intracellular signaling by linking …

MAPK modules are composed of a cascade of three intracellular protein kinases (MKKK, MKK and MAPK) which are activated successively by phosphorylation events. They are used to …

While a single MKKK can regulate several different MAPK family members, and several MKKKs can often activate the same MAPK, emerging evidence indicates a unique role for individual …