The global role of miRNA function in the heart has been addressed by conditionally inhibiting miRNA maturation in the murine heart. This revealed that miRNAs play an essential role during its development.

2023年6月28日 · Here, we summarize the current understanding of miRNA biogenesis, function and regulation, and outline challenges to address in the future.

They are powerful regulators of various cellular activities including cell growth, differentiation, development, and apoptosis. They have been linked to many diseases, and currently miRNA-mediated clinical trial has shown promising results for treatment of cancer and viral infection.

The first and last miRNA nucleotides clamp the miRNA within AGO proteins, and thus tags to these regions may affect miRNA functioning in unpredictable ways. Recent studies have shed light on the dynamic nature of miRNA actions and further revealed the complexity of miRNA-mediated gene regulation.

2025年1月23日 · A microRNA (miRNA) is a small molecule in cells, typically about 21–25 nucleotides in length, that plays a crucial role in the regulation of gene expression.

Differences Between Small Interfering RNA (siRNA) and Micro RNA (miRNA): Micro RNA [miRNA] is a short (about 21 to 23 nucleotides) single-stranded RNA molecule that is now recognized as playing an important role in gene regulation.

MicroRNAs (miRNAs), widely distributed, small regulatory RNA genes, target both messenger RNA (mRNA) degradation and suppression of protein translation based on sequence complementarity between the miRNA and its targeted mRNA. Different names have ...

Unique miRNA signatures of various inherited, metabolic, infectious, and neoplastic diseases have added a new dimension to the studies that look at their pathogenesis and highlight their potential to be reliable biomarkers.

2024年12月19日 · Lastly, we explore multiple regulatory layers of miRNA biogenesis, mediated by RNA–protein interactions, miRNA tailing (uridylation or adenylation) and RNA modifications.

2025年1月22日 · Modulating miRNA expression is one way to increase lifespan in animal models. A new study (Jan 2025) in mice used an oral miRNA compound to reverse aging. The researchers gave old mice exosomes containing miR-302b, which reversed cellular senescence. This is a cool study with nice pictures of old mice looking young, but cellular senescence is ...