2024年12月25日 · MFAP4 (Microfibril Associated Protein 4) is a Protein Coding gene. Diseases associated with MFAP4 include Smith-Magenis Syndrome and Leukoencephalopathy With Vanishing White Matter . Among its related pathways are Elastic fibre formation and Extracellular matrix organization .

2024年5月13日 · Microfibril-associated glycoprotein 4 (MFAP4) is a 36-kDa extracellular matrix glycoprotein with critical roles in organ fibrosis, chronic obstructive pulmonary disease, and cardiovascular...

2020年7月16日 · Microfibril-associated glycoprotein 4 (MFAP4) is an extracellular matrix protein belonging to the fibrinogen-related protein superfamily. MFAP4 is produced by...

2023年11月7日 · As the top hit, we identified Microfibril associated protein 4 (Mfap4). Knockdown of Mfap4 in hepatocytes enhances cell proliferation, accelerates liver regeneration, and attenuates chronic liver...

2020年7月16日 · Microfibril-associated glycoprotein 4 (MFAP4) is an extracellular matrix protein belonging to the fibrinogen-related protein superfamily. MFAP4 is produced by vascular smooth muscle cells and is highly enriched in the blood vessels of the heart and lung, where it is thought to contribute to the stru …

MFAP4 regulates integrin alphaVbeta3-induced VSMC proliferation and migration, as well as monocyte chemotaxis, and accelerates neointimal hyperplasia after vascular injury. Serum MFAP4 varies in groups of patients with different cardiovascular conditions.

2022年8月1日 · We summarize and discuss the tissue distribution of MFAP4 and its reported role in health as well as various disease processes. Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein belonging to the fibrinogen-related domain family.

2024年11月2日 · Integrated analysis of microfibrillar-associated proteins reveals MFAP4 as a novel biomarker in human cancers. Yang J, et al. Epigenomics, 2019 Jan. PMID 30089404. What's a GeneRIF? Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells.

MFAP4 is involved in organization of the ECM, regulating proper elastic fiber assembly. On the other hand, during pathology MFAP4 actively contributes to disease development and progression due to its interactions with RGD-dependent integrin receptors.

Microfibrillar-associated protein 4 (MFAP4) is located in the extracellular matrix (ECM). We sought to identify tissues with high levels of MFAP4 mRNA and MFAP4 protein expression.