Mesylate - an overview | ScienceDirect Topics
2011年12月13日 · Eribulin Mesylate (E7389): Review of Efficacy and Tolerability in Breast, Pancreatic, Head and Neck, and Non–Small Cell Lung Cancer. Sarah L. Scarpace PharmD, BCOP, in Clinical Therapeutics, 2012. Description. Eribulin mesylate is a nontaxane microtubule dynamics inhibitor.
Mesylate - an overview | ScienceDirect Topics
Nafamostat mesylate is a potent serine protease inhibitor that has been widely used in Japan for the treatment of acute pancreatitis, disseminated intravascular coagulation, and also as an anticoagulant in patients on hemodialysis. It can cause hyperkalemia primarily as metabolites of nafamostat inhibit these aldosterone-inducible, channel ...
Mesylate - an overview | ScienceDirect Topics
Gabexate mesylate (GM-Foy ®) is a synthetic inhibitor of trypsin-like serine proteases [71] with an antiproteinase activity on plasma proteases, including thrombin, plasmin, trypsin, kallikrein, C1 esterase in the complement system, and factor Xa in the coagulation cascade. This agent is utilized for treatment of disseminated intravascular ...
Mesylate - an overview | ScienceDirect Topics
The mesylate salt of 44 was first dosed in Mar. 2013 to patients with EGFRm + advanced NSCLC, who had disease progression following treatment with an EGFR TKI (including 1 or 2). Based on our preclinical data, the initial dose selected for oral …
Imatinib Mesylate - ScienceDirect
2014年1月1日 · Imatinib mesylate was the first molecularly targeted protein kinase inhibitor to receive FDA approval. It targets the BCR–ABL tyrosine kinase, which underlies CML. A single molecular event, in this case the 9:22 translocation, leads to expression of the ABL fused to BCR, yielding a constitutively activated protein kinase, BCR–ABL, and then ...
Mesylation - an overview | ScienceDirect Topics
The optimal temperature for the mesylation was found to be near ambient, with gentle heating affording essentially the same impurity profile (entries 3 and 4). Interestingly, running the mesylation at 0 °C resulted in higher amounts of mono-mesylate 27, possibly because of entrainment in the dimesylate 5a as it crystallized. The conditions in ...
Residues of genotoxic alkyl mesylates in mesylate salt drug …
2006年6月1日 · Under these reaction conditions, there seems to be negligible potential for alkyl mesylate formation, since this would involve nucleophilic displacement of hydroxide ion (an extremely poor leaving group) by mesylate ion (an extremely poor nucleophile owing to delocalisation of negative charge over three oxygen atoms, Fig. 2). If a slight excess ...
Imatinib Mesylate - ScienceDirect
2014年1月1日 · Imatinib mesylate (IBM) is a modern anti cancer agent, which is a site specific drug and has been used for the treatment of brain tumor, chronic myeloid leukemia (CML), gastrointestinal stromal tumors (GISTs), chronic myelomonocytic leukemia, hypereosinophilia syndrome and dermatofibrosarcoma protuberans [40–42].
Exogenous deferoxamine mesylate suppresses iron-dependent …
2025年1月1日 · Deferoxamine mesylate treatment suppressed the increase of H 2 O 2 or MDA content and the decline of GSH content, reduced the levels of ferrous ions and total iron ions, which contributed to the suppression of iron-dependent ROS accumulation and lipid peroxidation to completely attenuate cell death, as well as the reduction of Fenton reaction ...
Modulation of biopharmaceutical properties of drugs using …
2021年12月1日 · Mesylate salt is administered parenterally, while phentolamine HCl is administered orally. Thus, phentolamine mesylate is considered more useful and less toxic than the other [ 42 ]. Doxazosin is a quinazoline derivative, patented and launched by Pfizer Corp. [ 43 ] in 1978 and 1988, respectively, as an antihypertensive medication.