2024年12月25日 · MAPK8 (Mitogen-Activated Protein Kinase 8) is a Protein Coding gene. Diseases associated with MAPK8 include Hepatitis C and Hepatitis. Among its related pathways are Toll Like Receptor 3 (TLR3) Cascade and Prolactin Signaling.

MAPK8 expression is associated with a quantitative trait locus in patients with sickle cell disease and pulmonary hypertension. Our results imply that mesenchymal JNK has a pivotal role in the paracrine cross talk between dermal fibroblasts and …

2025年2月8日 · Title: MicroRNA miR-181d-5p regulates the MAPK signaling pathway by targeting mitogen-activated protein kinase 8 (MAPK8) to improve lupus nephritis. JNK mediates cell death by promoting the ubiquitination of the apurinic/apyrimidinic endonuclease APE1.

MAPK8, also known as SAPK/JNK, is a stress enzyme that plays a role in controlling differentiation by blocking totipotency maintained by Pou5F1 and polycombs in mammalian ES cells. AI generated definition based on: Developmental Biology, 2007

In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation (PubMed: 21095239).

2024年12月10日 · Clinical resource with information about MAPK8, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

The mitogen-activated protein kinases (MAPKs) are a family of serine-threonine protein kinases that participate in a major signaling system by which cells transduce extracellular stimuli into intracellular responses.

2003年1月1日 · Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase. Signal transduction by the JNK group of MAP kinases.

Enables JUN kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including JNK cascade; generation of neurons; and positive regulation of cellular protein metabolic process.

MAPK8; mitogen-activated protein kinase 8. Aliases: JNK, JNK1, PRKM8, SAPK1, JNK-46, JNK1A2, SAPK1c, JNK21B1/2. Location: 10q11.22. Summary: The protein encoded by this gene is a member of the MAP kinase family.