Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene. [5]

2024年12月25日 · MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7) is a Protein Coding gene. Diseases associated with MAP3K7 include Cardiospondylocarpofacial Syndrome and Frontometaphyseal Dysplasia 2. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Bacterial infections in CF airways.

MAP3K7 - mitogen-activated protein kinase kinase kinase 7 Gene. MAP3K7 - mitogen-activated protein kinase kinase kinase 7 Gene.

Mitogen‐activated protein 3 kinase 7 (MAP3K7) encodes the ubiquitously expressed transforming growth factor β‐activated kinase 1, which plays a crucial role in many cellular processes. Mutationsin the MAP3K7 gene have been linked to two distinct disorders: frontometaphyseal dysplasia type 2 (FMD2) and cardiospondylocarpofacial syndrome ...

Mitogen-activated protein 3 kinase 7 (MAP3K7) encodes the ubiquitously expressed transforming growth factor β-activated kinase 1, which plays a crucial role in many cellular processes. Mutationsin the MAP3K7 gene have been linked to two distinct disorders: frontometaphyseal dysplasia type 2 (FMD2) a …

MAP3K7 is an innate immune regulatory gene with increased expression in human and murine kidney intercalated cells following uropathogenic Escherichia coli exposure. Enhanced expression of mRNA for transforming growth factor beta activated kinase 1 in CD34+ cells of the bone marrow in rheumatoid arthritis.

2025年2月8日 · Insights into the molecular pathogenesis of cardiospondylocarpofacial syndrome: MAP3K7 c.737-7A > G variant alters the TGFβ-mediated α-SMA cytoskeleton assembly and autophagy.

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1.

2025年2月8日 · MAP3K7 is an innate immune regulatory gene with increased expression in human and murine kidney intercalated cells following uropathogenic Escherichia coli exposure. TAK1 protein kinase activity is required for TLR signalling …

2022年2月4日 · Using mass spectrometry, Wang et al. (2008) identified MAP3K7 as a component of the ADA2A (TADA2A; 602276)-containing (ATAC) histone acetyltransferase complex in HeLa cells. Pertel et al. (2011) demonstrated that TRIM5 (608487) promotes innate immune signaling and that this activity is amplified by retroviral infection and interaction with the ...