2024年12月25日 · MAGI3 (Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 3) is a Protein Coding gene. Diseases associated with MAGI3 include Endometrial Cancer. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Phospholipase-C Pathway.

2022年7月22日 · MAGI3 was identified as a novel substrate-binding subunit of SKP1-Cullin E3 ligase to recognize c-Myc, and process c-Myc ubiquitination and degradation. Expression of MAGI3 in CRC cells inhibited cell growth, promoted apoptosis and chemosensitivity to fluoropyrimidine-based chemotherapy by suppressing activation of c-Myc in vitro and in vivo.

2025年2月16日 · Through its interaction with the MAS receptor, MAGI3 has been identified as a regulator of cell proliferation and a determinant of Sunitinib resistance in ccRCC, operating via the Ang-...

2025年2月16日 · The loss of MAGI3 expression in ccRCC patients activated the ERK signaling pathway, contributing to both cancer progression and Sunitinib resistance. Therefore, our study not only highlight MAGI3's pivotal role in ccRCC progression and Sunitinib resistance, but also reinforces MAGI3's prospective value as a predictive marker.

本研究确定MAGI3是结直肠癌中的一种新的肿瘤抑制因子，并证明了它通过靶向c-Myc来抑制增殖。 该研究首次提供了令人信服的证据，证明MAGI3是一种新的E3泛素连接酶，通过降解c-Myc来调节结直肠癌的发生。 MAGI3基因缺失与后不良相关，是结直肠癌患者氟嘧啶类化疗的潜在预测生物标志物。 如他。 MAGI3基因检测对结直肠癌的术后辅助化疗是否和预后判断具有重要的经济和临床意义。 对患者来说是绝对的福音，当然，也有待大量的临床数据来支撑检验。 本文参阅生 …

MAGI3 - membrane associated guanylate kinase, WW and PDZ domain containing 3 Gene

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 is an enzyme that in humans is encoded by the MAGI3 gene. [5] [6] [7]

2025年2月17日 · magi3 是 ccrcc 的新型预后指标并参与 mapk 信号通路：通过对多个 ccrcc 数据集进行差异基因表达分析，研究人员鉴定出 984 个差异表达基因，其中 6 个富集通路与 mapk 级联相关。在 mapk 相关基因中，magi3 等 21 个基因与 ccrcc 患者的总生存期显著相关。

2022年8月17日 · 近日，来自首都医科大学的研究者们在Molecular Cancer杂志上发表了题为“E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a predictor for chemotherapy response in colorectal cancer”的文章，该研究揭示了MAGI3是一种新的E3泛素连接酶，通过降解c-Myc来调节结直肠癌的发生发展，可能成为结直肠癌患者辅助化疗的潜在预测指标。 在本研究中，研究者通过筛选差异表达基因 (DEG)、构建随机森林分类和对DEGS的重要性进行排序，研究者确定膜相 …

In the present study, we identified a PDZ protein, membrane-associated guanylate kinase inverted 3 (MAGI3) as a novel inhibitor of Wnt/β-catenin signaling and showed that it suppressed the malignant phenotypes of glioma cells. MAGI3 expression was negatively correlated with tumor grade and poor prognosis. RESULTS