MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2, which forms a heterodimer with MSH6 to make the human MutSα mismatch repair complex. It also dimerizes with …

2023年7月15日 · What does an MSH2 mutation mean for my blood relatives? If you have a mutation, your biological parents, siblings, and children each have a 50% chance of having the same mutation. Your distant family members may also be at risk for having the same mutation.

The MSH2 gene provides instructions for making a protein that plays an essential role in repairing DNA. This protein helps fix errors that are made when DNA is copied (DNA replication) in preparation for cell division.

The genes associated with Lynch syndrome are MLHL, MSH2, MSH6, PMS2 and EPCAM. Colon cancers caused by Lynch syndrome tend to be more common on the right side of the colon and develop much more quickly than in the general population (one to two years versus 10 years).

2024年12月25日 · MSH2 (MutS Homolog 2) is a Protein Coding gene. Diseases associated with MSH2 include Lynch Syndrome 1 and Muir-Torre Syndrome. Among its related pathways are DNA repair pathways, full network and Gene expression (Transcription). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding.

2022年8月23日 · Finding out you have an MSH2 gene mutation can be useful information for your family members. It can also help you better understand your cancer risk. Men and women with an MSH2 mutation have...

2024年9月6日 · MSH2 inherited mutations (Lynch Syndrome) may affect your options for cancer prevention, detection and treatment. FORCE is here to guide you.