Myosin Light Chain 2 Antibody detects endogenous levels of total Myosin Light Chain 2 (smooth muscle). This antibody does not cross-react with the cardiac isoform of Myosin Light Chain 2, or Myosin Essential Light Chain.

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) also known as the regulatory light chain of myosin (RLC) is a protein that in humans is encoded by the MYL2 gene. [5][6] This cardiac ventricular RLC isoform is distinct from that expressed in skeletal muscle (MYLPF), smooth muscle (MYL12B) and cardiac atrial muscle (MYL7).

Myosin light chains (MLCs) can be broadly classified into two groups: Regulatory MLC (MLC2 or RLC). Essential and regulatory MLCs have molecular masses of 22 and 19 kDa, respectively. Structurally, MLC2 contains a serine residue that is lacking in MLC1.

Myosin light chain-2 (MYL2, also called MLC-2) is an ∼19 kDa sarcomeric protein that belongs to the EF-hand calcium binding protein superfamily and exists as three major isoforms encoded by three distinct genes in mammalian striated muscle.

2024年12月25日 · MYL2 (Myosin Light Chain 2) is a Protein Coding gene. Diseases associated with MYL2 include Cardiomyopathy, Familial Hypertrophic, 10 and Myopathy, Myofibrillar, 12, Infantile-Onset, With Cardiomyopathy. Among its related pathways are Activation of cAMP-Dependent PKA and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases.

3 天之前 · The myosin regulatory light chain 2 (MLC2) is a crucial regulator of myosin activity. Its phosphorylation, mediated by various kinases, plays a vital role in maintaining normal physiological functions in skeletal muscle, myocardium, smooth muscle, and nonmuscle cells. Moreover, MLC2 has been implicated in the development of many cancers through its phosphorylation. An increasing number of ...

该基因编码哺乳动物横纹肌中的一种主要肌节蛋白。 编码的蛋白质在胚胎心肌结构和功能中发挥作用，而编码蛋白质的磷酸化参与成人的心肌肌球蛋白循环动力学、扭转和功能。 该基因的突变与肥厚性心肌病 10 和婴儿期肌病有关。 [RefSeq 提供，2022 年 5 月] This gene encodes a major sarcomeric protein in mammalian striated muscle.

2 天之前 · mlc 2 的磷酸化过程由多种激酶介导。 这些激酶如同一个个 “信号使者”，在不同的细胞环境和生理条件下被激活，然后将磷酸基团添加到 mlc 2 特定的氨基酸残基上，改变其结构和功能。 在骨骼肌、心肌、平滑肌以及非肌肉细胞中，不同的激酶参与其中，形成了一个复杂而有序的调 …

The myosin regulatory light chain 2 (MLC2) is a crucial regulator of myosin activity. Its phosphorylation, mediated by various kinases, plays a vital role in maintaining normal physiological functions in skeletal muscle, myocardium, smooth muscle, and nonmuscle cells. Moreover, MLC2 has been implica …

mlc2主要存在四种亚型：非肌型、平滑肌型、骨骼肌型和心肌型。 心肌型又有心房型(MLC2a)和心室型(MLC2v)，这两型的基因具有高度同源性，它们的初级氨基酸序列有56%的一致性和86%的相似性[7]。