Monocarboxylate transporter 4 (MCT4) also known as solute carrier family 16 member 3 is a protein that in humans is encoded by the SLC16A3 gene. [5] [6]

MCTs 1 – 4 are proton-dependent transporters and are well characterized due to their critical role in the transport of products of the glycolysis cycle (i.e., lactate and pyruvate), as well as ketone …

2019年6月14日 · In human and other mammalian cells, transport of L -lactate across plasma membranes is mainly catalyzed by monocarboxylate transporters (MCTs) of the SLC16 solute …

2023年1月27日 · As MCT4 is involved in some of these mechanisms, we hypothesized that MCT4 could be an important target molecule for cancer therapy. Metabolic reprogramming of cancer …

2025年3月5日 · MCT4 is a lactate transporter associated with glycolysis, which has been found to be associated with various tumorigenesis and development processes. Gastric cancer is a …

The monocarboxylate transporters, [1] or MCTs, are a family of proton -linked plasma membrane transporters that carry molecules having one carboxylate group (monocarboxylates), such as …

As mediators of H + ‐coupled translocation of L‐lactate, pyruvate, and ketone bodies across cell membranes, MCT1–MCT4 support the maintenance of an energy balance and pH …

Monocarboxylate transporter 4 (MCT4) is an H+-coupled symporter highly expressed in metastatic tumors and at inflammatory sites undergoing hypoxia or the Warburg effect. At …

2017年10月12日 · We suggest that upregulation of MCT1- and MCT4-mediated lactate flux capacity and NBCe1-mediated HCO 3 − /pH homeostasis are important for the physiological …

Using a cell-based screen in a MCT4-dependent cell line, we identified and optimized compounds for their ability to inhibit the efflux of intracellular lactic acid with good physical and …