Monocarboxylate transporter 4 (MCT4) also known as solute carrier family 16 member 3 is a protein that in humans is encoded by the SLC16A3 gene. [5] [6]

MCTs 1 – 4 are proton-dependent transporters and are well characterized due to their critical role in the transport of products of the glycolysis cycle (i.e., lactate and pyruvate), as well as ketone bodies (such as acetoacetate and β -hydroxybutyrate) across the plasma membrane.

2019年6月14日 · In human and other mammalian cells, transport of L -lactate across plasma membranes is mainly catalyzed by monocarboxylate transporters (MCTs) of the SLC16 solute carrier family. MCTs play an...

2023年1月27日 · As MCT4 is involved in some of these mechanisms, we hypothesized that MCT4 could be an important target molecule for cancer therapy. Metabolic reprogramming of cancer cells is a potential...

2025年3月5日 · MCT4 is a lactate transporter associated with glycolysis, which has been found to be associated with various tumorigenesis and development processes. Gastric cancer is a malignant disease with high incidence and mortality. The role of MCT4 in the occurrence and development of gastric cancer has not been clarified. In this study, we comprehensively …

The monocarboxylate transporters, [1] or MCTs, are a family of proton -linked plasma membrane transporters that carry molecules having one carboxylate group (monocarboxylates), such as lactate, pyruvate, and ketones across biological membranes. [2] .

As mediators of H + ‐coupled translocation of L‐lactate, pyruvate, and ketone bodies across cell membranes, MCT1–MCT4 support the maintenance of an energy balance and pH homeostasis and enable metabolic cooperation between different tissues with distinct energetic profiles.

Monocarboxylate transporter 4 (MCT4) is an H+-coupled symporter highly expressed in metastatic tumors and at inflammatory sites undergoing hypoxia or the Warburg effect. At these sites, extracellular lactate contributes to malignancy and immune response evasion.

2017年10月12日 · We suggest that upregulation of MCT1- and MCT4-mediated lactate flux capacity and NBCe1-mediated HCO 3 − /pH homeostasis are important for the physiological function of mature adipocytes.

Using a cell-based screen in a MCT4-dependent cell line, we identified and optimized compounds for their ability to inhibit the efflux of intracellular lactic acid with good physical and pharmacokinetic properties.