Monocarboxylate transporter 4 (MCT4) also known as solute carrier family 16 member 3 is a protein that in humans is encoded by the SLC16A3 gene. [5] [6]

2023年1月27日 · As MCT4 is involved in some of these mechanisms, we hypothesized that MCT4 could be an important target molecule for cancer therapy. Metabolic reprogramming of cancer …

2017年10月12日 · We suggest that upregulation of MCT1- and MCT4-mediated lactate flux capacity and NBCe1-mediated HCO 3 − /pH homeostasis are important for the physiological …

Monocarboxylate transporter 4 (MCT4) is an H+-coupled symporter highly expressed in metastatic tumors and at inflammatory sites undergoing hypoxia or the Warburg effect. At …

2021年6月25日 · Moreover, monocarboxylate transporter 4 (MCT4) is overexpressed in solid cancers and plays a role in cancer cell proliferation and survival. Here, we report that MCT4 is …

In this study, we analyzed relevant databases to predict differential expression, clinical prognosis, gene enrichment and the relationship with immune infiltration of SLC16A3 in both lung …

2024年8月16日 · Monocarboxylate transporter 4 (Mct4) transports intracellular lactate outside, but its role in regulating host immune response against Mtb infection remains unknown. Mct4 …

Background: Glycolysis has an important role in inflammation. Results: MCT4 is up-regulated in inflammatorily activated macrophages and required for innate immune response. Conclusion: …

2018年8月28日 · MCT4 is a H + -linked lactate transporter which functions to facilitate lactate efflux from highly glycolytic cells. High MCT4 levels in HNSCC have been associated with poor …

We found that MCT4 deficiency substantially impeded cholesterol accumulation (Figures 1J, S1K, and S1L) and Dil-ox-LDL uptake (Figure 1K), leading to less FC formation. Moreover, MCT4 …