Monocarboxylate transporter 4 (MCT4) also known as solute carrier family 16 member 3 is a protein that in humans is encoded by the SLC16A3 gene. [5] [6]

2023年1月27日 · As MCT4 is involved in some of these mechanisms, we hypothesized that MCT4 could be an important target molecule for cancer therapy. Metabolic reprogramming of cancer cells is a potential...

2017年10月12日 · We suggest that upregulation of MCT1- and MCT4-mediated lactate flux capacity and NBCe1-mediated HCO 3 − /pH homeostasis are important for the physiological function of mature adipocytes.

Monocarboxylate transporter 4 (MCT4) is an H+-coupled symporter highly expressed in metastatic tumors and at inflammatory sites undergoing hypoxia or the Warburg effect. At these sites, extracellular lactate contributes to malignancy and immune response evasion.

2021年6月25日 · Moreover, monocarboxylate transporter 4 (MCT4) is overexpressed in solid cancers and plays a role in cancer cell proliferation and survival. Here, we report that MCT4 is exclusively expressed...

In this study, we analyzed relevant databases to predict differential expression, clinical prognosis, gene enrichment and the relationship with immune infiltration of SLC16A3 in both lung adenocarcinoma (LUAD) and squamous carcinoma (LUSC).

2024年8月16日 · Monocarboxylate transporter 4 (Mct4) transports intracellular lactate outside, but its role in regulating host immune response against Mtb infection remains unknown. Mct4 expression was upregulated in Mtb-infected macrophages and in patients with TB.

Background: Glycolysis has an important role in inflammation. Results: MCT4 is up-regulated in inflammatorily activated macrophages and required for innate immune response. Conclusion: MCT4 up-regulation represents a positive feedback mechanism in ...

2018年8月28日 · MCT4 is a H + -linked lactate transporter which functions to facilitate lactate efflux from highly glycolytic cells. High MCT4 levels in HNSCC have been associated with poor prognosis, but the role of MCT4 in the development and progression of this cancer is …

We found that MCT4 deficiency substantially impeded cholesterol accumulation (Figures 1J, S1K, and S1L) and Dil-ox-LDL uptake (Figure 1K), leading to less FC formation. Moreover, MCT4 deficiency directly led to intracellular lactate accumulation (Figure 1L).