2024年12月25日 · MBD2 (Methyl-CpG Binding Domain Protein 2) is a Protein Coding gene. Diseases associated with MBD2 include Klatskin's Tumor and Tetralogy Of Fallot. Among its related pathways are RNA Polymerase I Promoter Opening and …

2023年7月13日 · These findings suggest that Mbd2 is a novel epigenetic regulator of genes that are associated with ASD in humans. Mbd2 loss causes behavioral alterations that resemble those found in ASD...

MBD2 seems to play a selective role in gene repression depending on the CpG content of the promoter region; Methylated DNA binding domain protein 2 (MBD2) coordinately silences gene expression through activation of the microRNA hsa-mir-496 promoter in breast cancer cell line.

2023年6月29日 · Two members of the Methyl-CpG-binding domain (MBD) protein family, MBD2 and MBD3, are known to be integral, but mutually exclusive subunits of the NuRD complex. Several MBD2 and MBD3...

MBD2 has been linked to immune system function and tumorigenesis, yet little is known about its functions in vivo. Recent studies have found the MBD2 protein is ubiquitously expressed, with relatively high levels in the lung, liver, and colon.

2014年12月9日 · This review focuses on two members of the methyl binding proteins, namely MBD2 and MBD3 that reside in very similar complexes, yet appear to have very different biological roles. We provide a comprehensive comparison of their genome-wide binding features and emerging roles in gene regulation.

2024年4月1日 · MBD2 was found to control several genes involved in how cancer progresses and how the immune system responds.

MBD2 is a transcriptional repressor that specifically binds to methylated DNA and is a component of the MeCP1 protein complex. In contrast, MBD3 fails to bind methylated DNA in murine cells, and is a component of the Mi-2/NuRD corepressor complex.

MBD2 aggravates pulmonary fibrosis by enhancing TGF-β/Smad signaling. MBD2 promotes Th17 cell differentiation by downregulating SOCS3 expression. MBD2 inhibits the expression of Ship, enhances the PI3K/PKB signaling pathway, and then induces pulmonary fibrosis.

2025年2月8日 · Mbd2, which recruits co-repressor complexes to methylated DNA, is essential for efficient tumorigenesis in the intestine. MBDin relieves MBD2 repression potential and reactivates transcription from methylated promoters; MBD2 and Sp3 are involved in transcriptional repression of the mouse delta-opioid receptor gene