2024年12月25日 · MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) is a Protein Coding gene. Diseases associated with MAP3K1 include 46,Xy Sex Reversal 6 and 46,Xy Complete Gonadal Dysgenesis. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and TNFR1 Pathway.

The MAP3K1 gene provides instructions for making a protein that helps regulate signaling pathways that control various processes in the body, including the processes of determining sex characteristics before birth. Learn about this gene and related health conditions.

MAP3K1 is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family of serine/threonine kinases. MAP3K1 regulates JNK activation and is unique among human kinases in that it also encodes an E3 ligase domain that ubiquitylates c-Jun and ERK1/2.

2018年5月24日 · Our findings suggest that cancers having mutations in MAP3K1 or MAP2K4, which are frequent in tumors of breast, prostate and colon, may respond to MEK inhibitors.

Mitogen-activated protein kinase kinase kinase 1 facilitates the temozolomide resistance and migration of GBM via the MEK/ERK signalling. MAP3K1 expression is associated with progression and poor prognosis of hormone receptor …

2024年11月12日 · Mechanistically, MAP3K1 mutation suppressed MHC-I–mediated tumor antigen presentation through promoting the degradation of antigen peptide transporter 1/2 (TAP1 / 2) mRNA, thereby driving tumor immune escape.

Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (MAP3K1) is a gene that encodes a protein that functions as a serine/threonine kinase in multiple cell signaling cascades.

2024年10月17日 · MAP3K1, or MEKK1, is a mitogen-activated protein kinase (MAPK) kinase kinase that regulates the ERK (see 601795) and JNK (see 601158) MAPK pathways, as well as the transcription factor NF-kappa-B (see 164011) and …

MAP3K1. MAP3K1 is required for MAPK signal transmission by activating MAP2K1/4/7. MAP3K1 regulates the proliferation of invariant natural killer T cells and promotes the generation of T helper 2 (Th2) cytokines ; in addition, it is essential for B cell proliferation and antibody production .

2013年8月22日 · Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1.