2024年12月25日 · LSM7 (LSM7 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated) is a Protein Coding gene. Diseases associated with LSM7 include Leukodystrophy and Hypomyelinating Leukodystrophy. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and Deadenylation-dependent mRNA decay.

U6 snRNA-associated Sm-like protein LSm7 is a protein that in humans is encoded by the LSM7 gene. [5] [6] [7]

2022年6月28日 · The dynamic Lsm7 phase-separated condensates appear to work as seeding scaffolds, promoting Pab1 demixing and subsequent SG initiation, seemingly mediated by RNA interactions.

2024年11月1日 · In this study, LSM7 was prominently expressed in metastatic breast cancer tissues and was associated with poor prognosis in patients with BC. LSM7 was shown to enhance BC cell invasion and metastasis by upregulating the expression of CD44s, an alternatively spliced isoform of CD44.

2024年11月1日 · Aims: The RNA-binding protein LSM7 is essential for RNA splicing, acting as a key component of the spliceosome complex; however, its specific role in breast cancer (BC) has not been extensively investigated. Materials and methods: LSM7 expression in BC samples was evaluated through bioinformatics analysis and immunohistochemistry. The impact of ...

2025年2月8日 · RNA-binding protein LSM7 facilitates breast cancer metastasis through mediating alternative splicing of CD44. LSm1-7 proteins colocalize with DCP1,DCP2 and Xrn1 in cytoplasmic foci

2014年2月11日 · Analysis by mass spectrometry confirmed the presence of all seven Lsm proteins. Despite rigorous trials, we were unable to crystallize the Lsm1-7 complex. To solve this problem, we launched a...

2025年1月9日 · LSM7 encodes a subunit of the LSM complex, involved in pre-RNA maturation and mRNA degradation. Consequently, it has been suggested as a strong candidate disease gene. This hypothesis was supported by functional investigations of the variants.

2013年11月17日 · Here we report the crystal structures of the heptameric Lsm complex, both by itself and in complex with a 3′ fragment of U6 snRNA, at 2.8 Å resolution. Each of the seven Lsm proteins interacts with...

Correlations of LSM1, LSM2, LSM3, LSM4, LSM7, and LSM14B expressions with immune infiltration profiles in breast cancer (from TCGA database). The figures show the each LSM gene expression was associated with tumor purity and several tumor-infiltrating immune cell markers, namely CD8+ T cells, B cells, CD4+ T cells, neutrophils, macrophages, and ...