Three approaches to harness tumor suppressor miRNAs, such as let-7, for therapeutic purposes have been described, including: (1) the utilization of recombinant lentiviruses or adenoviruses expressing let-7 miRNAs in tumor cells as a type of gene therapy, (2) the administration of small molecules that epigenetically enhances endogenous let-7 ...

2008年10月1日 · let-7 remains one of the key miRNA regulators in development and cancer. The let-7-family miRNAs are highly conserved across animal species in sequence, at what developmental stage they are expressed and in their organization as clusters or within specific coding genes in the genome.

2015年6月1日 · Here, we show that let-7b contributes to the maintenance of genomic balance via targeting Aurora B kinase, a key regulator of the spindle assembly checkpoint (SAC). Our results indicate that let-7b binds to Aurora B kinase 3′UTR reducing mRNA …

2010年1月19日 · Neural stem cell self-renewal and differentiation is orchestrated by precise control of gene expression involving nuclear receptor TLX. Let-7b, a member of the let-7 microRNA family, is expressed in mammalian brains and exhibits increased expression during neural differentiation.

2017年6月12日 · We now report that let-7b and let-7c can positively regulate cellular H2Bub1 levels. Overexpression of let-7b and let-7c in a variety of non-transformed and cancer-derived cell lines...

Title: Exosomes derived from M1 macrophages inhibit the proliferation of the A549 and H1299 lung cancer cell lines via the miRNA-let-7b-5p-GNG5 axis. Expression analysis of miRNA hsa-let7b-5p in naso-oropharyngeal swabs of COVID-19 patients supports its role in regulating ACE2 and DPP4 receptors.

2022年11月15日 · Knockdown of let-7b in LAMs could inhibit the development of AML by repolarizing LAMs towards M1-subtype characteristics through the activation of Toll Like Receptor (TLR) and NF-κB pathway. Our study provides insight for future LAM-based immunotherapy strategies for AML.

We aimed to evaluate Sirtuin-1 mRNA and let-7b microRNA gene expression in breast cancer patients in Egypt and to relate them with clinicopathological features.

Additional characterization of let-7b induced miniature EPSCs (mEPSCs) in lamina IIo neurons of spinal cord slices. A and D, mEPCS traces showing the effects of 1-min perfusion of 7 µM of let-7b (A) and mutant oligos (D). The traces of (i) and (ii) are enlarged in bottom traces in short time scale. (B, C, E, F), quantification

2024年2月16日 · In this study, we found that let-7b-5p expression levels closely correlated with WHO grades and overall survival in patients in tumor glioma-CGGA-mRNAseq-325, and the upregulation of let-7b-5p can inhibit the proliferation and induce apoptosis of glioma cells.