The low-density lipoprotein receptor (LDL-R) is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) [5] that mediates the endocytosis of cholesterol-rich low-density lipoprotein (LDL).

ldlr，低密度脂蛋白受体相关蛋白是近年来发现的一种细胞表面蛋白,属于一种内吞性受体,系低密度脂蛋白受体基因家族中的一员.由于其能够与多种结构及功能各异的配体相互作用,不仅可以对血脂的动态平衡及纤溶功能的稳定进行调节,而且能参与多种生长因子 ...

2024年12月25日 · LDLR (Low Density Lipoprotein Receptor) is a Protein Coding gene. Diseases associated with LDLR include Hypercholesterolemia, Familial, 1 and Homozygous Familial Hypercholesterolemia. Among its related pathways are Familial hyperlipidemia type 1 and Statin inhibition of cholesterol production.

Low density lipoprotein receptor (LDLR) is responsible for uptake of cholesterol-carrying lipoprotein particles into cells. The receptor binds lipoprotein particles at the cell surface and releases them in the low-pH environment of the endosome. 低密度脂蛋白受体 (LDLR) 负责将携带胆固醇的脂蛋白颗粒吸收到细胞中。

LDLR is a cell membrane glycoprotein that functions in the binding and internalizing of circulating cholesterol-containing lipoprotein particles. LDLR is ubiquitously expressed and is a key receptor for maintaining cholesterol homeostasis in mammals. LDLR-mediated endocytosis is essential for lipoprotein and lipid metabolism .

The LDLR gene provides instructions for making a protein called the low-density lipoprotein receptor. This receptor binds to particles called low-density lipoproteins (LDLs), which are the primary carriers of cholesterol in the blood.

The role of these receptor proteins in pathogenesis of diverse metabolic risk factors is emerging, rendering them targets of novel therapeutics for metabolic syndrome and atherosclerosis. This manuscript reviews the physiological role of the LDLR family of proteins and describes its involvement in pathogenesis of hyperlipidemia and atherosclerosis.

2024年12月11日 · We established a platform for in-depth functional profiling of LDLR variants regarding cellular LDL uptake and LDLR expression, utilizing robotics and multiplexed high-content microscopy. This is the largest study providing functional data on cellular LDLR activity for 315 LDLR variants.

2025年3月12日 · LDLR (low-density lipoprotein receptor) is a long-lived type 1 transmembrane protein that undergoes multiple rounds of internalization and recycling between the cell surface and the endosomes by means of clathrin-mediated endocytosis. 1 Without ligand binding, LDLR keeps internalizing and recycling. Low-density lipoprotein (LDL) binding promotes the formation of clathrin-coated vesicles (CCVs ...

低密度脂蛋白受体 (low-density lipoprotein receptor，LDLR)是血脂载体低密度脂蛋白 (low-density lipoprotein，LDL)代谢途径中的关键介质，其功能紊乱或表达异常与MS各组分的发生发展存在密切的相关性。 随着分子生物学技术的进步，与LDLR相关的MS治疗靶点也获得了广泛研究。 本文就LDLR及与MS间的相关性研究进展作一综述。 LDLR由LDLR基因编码，在人类基因组中长度约45 kb，包含18个外显子和17个内含子。 LDLR是由839个氨基酸残基组成、包含5个功能结构域 …