Initially, two lipoxins were identified, lipoxin A 4 (LXA 4) and LXB 4, but more recent studies have identified epimers of these two LXs: the epi-lipoxins, 15-epi-LXA 4 and 15-epi-LXB 4 respectively. LXA 4 and LXB 4 were first described by Serhan, Hamberg, and the Nobel laureate Samuelsson in …

2024年4月26日 · LXA4 treatment protects against oxidative stress-induced H 2 O 2 damage by reducing ROS, lactate dehydrogenase (LDH), and malondialdehyde (MDA) leakage, while increasing antioxidant superoxide dismutase (SOD) .

Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways.

2024年11月21日 · The preclinical study, published in Cardiovascular Diabetology, found LXA4, which is known for its "calming agent" action in turning off the body's inflammatory response and preventing chronic...

2018年5月1日 · Lipoxin A4 (LXA4) is an immunoresolvin family member derived from arachadonic acid that signals primarily through the formyl peptide receptor 2 (FPR2). Limited reports investigate the relationship between LXA4, MCs and cutaneous inflammation.

2022年11月4日 · Lipoxin A4 (LXA4) is a specialized pro-resolving mediator involved in the resolution phase of inflammation that is crucial for the return of tissues to homeostasis, healing, and regenerative processes. LXA4 can modify the microenvironment via its receptor, formyl peptide receptor 2 (FPR2) and thus modulate the inflammatory response.

Lipoxin A4: Produced by the metabolism of 15-HETE or 15-HpETE with leukocytes. CAS Number: 89663-86-5. Synonyms: LXA4, 5(S),6(R),15(S)-TriHETE. Purity: ≥95%.

15(R)-Lipoxin A4: An aspirin-triggered lipoxin. CAS Number: 171030-11-8. Synonyms: AT-Lipoxin A4, 15-epi Lipoxin A4, 15(R)-LXA4. Purity: ≥95%.

15 (R)-Lipoxin A4 (15-epi-LXA4) is a STAT-6 activator and a lipid-derived lipoxin-type specialized pro-resolving mediator (SPM) that plays a role in promoting inflammation resolution and regulating immune cell function. 15 (R)-Lipoxin A4 can improve the phagocytic function of microglia and exhibits anti-inflammatory activity.

Acetylation of cyclooxygenase-2 (COX-2) by aspirin can trigger 15-epi-LXA4 (ATL) biosynthesis. Elucidating the pharmacological actions of lipoxins and ATL was facilitated by total synthesis of LXA4 in 1988 by Nicolaou and colleagues.