Liver receptor homolog-1: structures, related diseases, and drug ...
2024年4月17日 · Liver receptor homolog-1 (LRH-1), a member of the nuclear receptor superfamily, is a ligand-regulated transcription factor that plays crucial roles in metabolism, …
Pharmacological LRH-1/Nr5a2 inhibition limits pro-inflammatory cytokine ...
2020年2月28日 · Liver receptor homolog-1 (LRH-1, Nr5a2) is an orphan nuclear receptor mainly expressed in tissues of endodermal origin, where its physiological role has been extensively...
Emerging functions of the nuclear receptor LRH-1 in liver …
2021年8月1日 · LRH-1 is a key regulator of bile acid, lipid, glucose and methyl group homeostasis. LRH-1 coordinates several cellular stress responses in the liver. LRH-1 is a …
LRH-1: an orphan nuclear receptor involved in development, …
2004年5月1日 · The liver receptor homolog-1 (LRH-1; NR5A2) and steroidogenic factor-1 (SF-1; NR5A1) are two orphan members of the Ftz-F1 subfamily of nuclear receptors. LRH-1 is …
Liver receptor homolog-1 (NR5A2) orchestrates hepatic ... - Cell …
The nuclear receptor liver receptor homolog-1 (LRH-1) is highly expressed in tissues of endodermal origin and exhibits wide-ranging functions. 1, 2 LRH-1 is essential during early …
The orphan nuclear receptor LRH-1/NR5a2 critically regulates T …
2019年7月17日 · LRH-1 (liver receptor homolog-1/NR5a2) is an orphan nuclear receptor, which regulates glucose and lipid metabolism, as well as intestinal inflammation via the …
The orphan nuclear receptor LRH-1/NR5a2 critically regulates
2019年7月17日 · LRH-1 (liver receptor homolog-1/NR5a2) is an orphan nuclear receptor, which regulates glucose and lipid metabolism, as well as intestinal inflammation via the …
LRH-1: an orphan nuclear receptor involved in ... - ScienceDirect
2004年5月1日 · The liver receptor homolog-1 (LRH-1; NR5A2) and steroidogenic factor-1 (SF-1; NR5A1) are two orphan members of the Ftz-F1 subfamily of nuclear receptors. LRH-1 is …
Molecular basis for the regulation of the nuclear receptor LRH-1
2014年11月15日 · Liver receptor homolog-1 (LRH-1) is a nuclear receptor (NR) with diverse functions in development, differentiation and metabolism and has been extensively studied in …
Discovery of the First Low Nanomolar Liver Receptor Homolog-1 (LRH-1 ...
2019年11月21日 · Here we show that LRH-1 maintains intestinal epithelial health and protects against inflammatory damage. Knocking out LRH-1 in murine intestinal organoids reduces …
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