2022年7月4日 · The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a target for therapeutic immunomodulation to...

2024年6月1日 · Voltage-gated potassium channel 1.3 (Kv1.3) has emerged as a pivotal player in numerous biological processes and pathological conditions, sparking considerable interest as a potential therapeutic target across various diseases.

Therapeutic targeting K V 1.3 with specific peptides and small molecule inhibitors shows great potential for treating cancers and autoimmune diseases, such as multiple sclerosis, type I diabetes mellitus, psoriasis, contact dermatitis, rheumatoid arthritis, and myasthenia gravis.

2020年1月13日 · Kv1.3 channel blockers have been found to alleviate disease symptoms in animal autoimmune diseases, chronic inflammatory diseases, and metabolic disease models without obvious side effects (Perez-Verdaguer et al., 2016).

2024年9月4日 · Kv1.3 is a multifunctional potassium channel implicated in multiple pathologies, including cancer. However, how it is involved in disease progression is not fully clear. We interrogated the interactome of Kv1.3 in intact cells using BioID proximity labeling, revealing that Kv1.3 interacts with STAT3– and p53–linked pathways.

2017年3月1日 · Electrophysiology studies have implicated the potassium ion (K +) channel Kv1.3 as having a critical role in the regulation of chronically activated effector memory T (T EM) cell immune...

2021年2月6日 · Since the discovery of the Kv1.3 voltage-gated K+ channel in human T cells in 1984, ion channels are considered crucial elements of the signal transduction machinery in the immune system.

Introduction: Kv1.3 is the main voltage-gated potassium channel of leukocytes from both the innate and adaptive immune systems. Channel function is required for common processes such as Ca 2+ signaling but also for cell-specific events.

2021年4月7日 · We show Kv1.3 channels regulate respiration through a non-conducting mechanism to generate reactive oxygen species which drive proliferation.

2022年7月4日 · The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a target for therapeutic immunomodulation to block its activity and suppress T cell activation.

ShK and Kv1.3 blocking polypeptides as potential therapeutic agents for neuroinflammatory diseases. ShK and Kv1.3 toxins might be used to treat multiple sclerosis, and other neuroinflammatory disorders via inhibiting Kv1.3 expressed in T …

2022年7月22日 · This study visualizes Kv1.3 pore dynamics, defines two distinct mechanisms to suppress Kv1.3 channel activity with exogenous inhibitors, and provides a framework to aid development of emerging T cell immunotherapies.

2019年9月23日 · Channel activation enables transportation of potassium ions down their electrochemical gradient. Kv1.3 channel is expressed in many cell types, both normal and cancer. Activity of the channel plays an important role in cell proliferation and apoptosis.

2020年7月10日 · Here, we give a short overview of the main characteristics of Kv1.3 channels and then focus on recent advances in the use of Kv1.3 blockers in the treatment of hematological malignancies, proposing memantine as a valuable Kv1.3 channel inhibitor for clinical application.

The voltage-dependent potassium channel Kv1.3 is a potential target for cancer therapies. This channel exhibits a complex repertoire of physiological functions such as proliferation, activation, insulin sensitivity, nerve action potential and apoptosis among others.

Since the discovery of the Kv1.3 voltage-gated K + channel in human T cells in 1984, ion channels are considered crucial elements of the signal transduction machinery in the immune system. Our knowledge about Kv1.3 and its inhibitors …

2022年4月19日 · The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a target for therapeutic immunomodulation to block its activity and suppress T cell activation.

2020年11月1日 · In this study, treatment of ureteral unilateral obstruction rats using the Kv1.3-blocking peptide MgTx reduced the size of the kidney cortical interstitium and decreased the number of myofibroblasts in the kidney.

Results: Kv1.3 in the nucleus regulates nuclear membrane potential and activates transcription factors. Conclusion: Kv1.3 is a functional channel at the nucleus. Significance: This study provides novel insight about functional nuclear Kv1.3 and expands our knowledge about the function of ion channels within the nucleus.

2003年6月1日 · Activated myelin-reactive T cells from patients with MS exhibited the Kv1.3 high IKCa1 low T EM phenotype, suggesting that they have undergone repeated stimulation during the course of disease; these cells may contribute to disease pathogenesis due to their ability to home to inflamed tissues and exhibit immediate effector function.