2024年12月25日 · KDM3A (Lysine Demethylase 3A) is a Protein Coding gene. Diseases associated with KDM3A include Prostate Cancer and Autism Spectrum Disorder. Among its related pathways are NR1H2 and NR1H3-mediated signaling and Chromatin organization.

KDM3A demethylates H3K9me1/me2 to increase gene transcription and plays key roles in spermatogenesis , energy metabolism , stem cell regulation , and sex determination . Moreover, increasing evidence has indicated the key roles of KDM3A in promoting cancer progression.

2022年3月25日 · Our prior studies have characterized the participation of histone demethylase KDM3A in diabetic vascular remodeling, while its roles in myocardial ischemia/reperfusion (I/R) injury (MIRI) remain...

2018年12月7日 · Here, we investigate gain and loss of function of an H3K9me2 specific demethylase, Kdm3a, and show it promotes LVH and fibrosis in response to pressure-overload. Cardiomyocyte KDM3A activates...

Histone modification alters chromatin architecture to regulate gene transcription. KDM3A is a histone demethylase in the JmjC domain-containing protein family. It removes di- and mono- methyl residues from di- or mono-methylated lysine 9 of histone H3 (H3K9me2/me1).

Background & aims: The histone lysine demethylase 3A (KDM3A) demethylates H3K9me1 and H3K9Me2 to increase gene transcription and is upregulated in tumors, including pancreatic tumors.

2025年2月9日 · KDM3A is tyrosine-phosphorylated by JAK2 in the nucleus and functions as a STAT3-dependent transcriptional coactivator. Lysine demethylase 3A (KDM3A) is upregulated in myocardium from patients with hypertrophic heart disease.

The lysine demethylase 3A (KDM3A, JMJD1A or JHDM2A) controls transcriptional networks in a variety of biological processes such as spermatogenesis, metabolism, stem cell activity, and tumor progression. We matched transcriptomic and ChIP-Seq ...

2025年1月5日 · Title: Knockout of KDM3A in MDA-MB-231 breast cancer cells inhibits tumor malignancy and promotes apoptosis. KDM3A promotes oral squamous cell carcinoma cell proliferation and invasion via H3K9me2 demethylation-activated DCLK1.

2019年12月19日 · We demonstrated that lysine demethylase 3A (KDM3A) binds to PGC-1α and demethylates monomethylated lysine (K) 224 of PGC-1α under normoxic conditions. Hypoxic stimulation inhibits KDM3A, which has a high K M of oxygen for its activity, and enhances PGC-1α K224 monomethylation.