The KCCQ measures symptoms, physical and social limitations, and quality of life in patients with heart failure. • In clinical trials, mean differences in KCCQ scores are more difficult to interpret than the proportion of patients experiencing clinically important changes. •

Recommended threshold scores have been reported for poor, fair, good, and excellent levels of functioning on the KCCQ overall summary score (OSS): ≤25, >25 to 50, >50 to 75, and >75 to 100, respectively. 9 These quartile ranges were used successfully in drug trials such as EPHESUS 2 to predict clinical outcomes at 2 years. However, a ...

2025年2月1日 · Cross-sectionally, the KCCQ-23 Overall Summary Scores (KCCQ-23 OSS) and Clinical Summary Scores (KCCQ-23 CSS) had an inverse relationship with the NYHA class at baseline and 30 weeks, with marked variations in KCCQ-23 scores among patients assigned to the same NYHA class.

The KCCQ instrument may be used by medical device companies and sponsor-investigators for evaluation of safety and effectiveness for heart failure medical devices to support regulatory...

Kansas City Cardiomyopathy Questionnaire (KCCQ-12) The following questions refer to your heart failure and how it may affect your life. Please read and complete the following questions. There are no right or wrong answers. Please mark the answer that best applies to you. 1. Heart failure affects different people in different ways. Some feel ...

Results of this study suggest that clinical trials should explicitly describe the distributions of KCCQ change at the patient level within treatment groups to support the clinical interpretation of their results.

The main objective of this study was to correlate the changes in the KCCQ and Patient Global Assessment (PGA) in patients with HF with reduced ejection fraction (HFrEF) to determine minimal clinically important difference (MCID). Methods and results: We analysed data from 459 patients of the FAIR-HF trial. Both KCCQ and PGA were assessed at 4 ...

2020年11月17日 · This review describes how to interpret the KCCQ, how it should be analyzed in clinical trials to maximize the interpretability of results, and how it can be used in clinical practice and population health.

2024年11月15日 · Importance: The Kansas City Cardiomyopathy Questionnaire (KCCQ) is a commonly used outcome in heart failure trials. While comparing means between treatment groups improves statistical power, mean treatment effects do not necessarily reflect the clinical benefit experienced by individual patients.

This review describes how to interpret the KCCQ, how it should be analyzed in clinical trials to maximize the interpretability of results, and how it can be used in clinical practice and population health.

2022年8月1日 · The KCCQ summary scores (KCCQ-OS, KCCQ-CS, and KCCQ Total Symptom scores) were compared with the NYHA functional class at baseline. They were also compared with the HCMSQ Shortness of Breath, Tiredness, and Cardiovascular Symptoms domains, with a focus on the latter to explore how well the scores correlated with symptoms that were not …

The Kansas City Cardiomyopathy Questionnaire (KCCQ) is a new, self-administered, 23-item questionnaire that quantifies physical limitations, symptoms, self-efficacy, social interference and quality of life.

Therefore, we aimed to assess the KCCQ’s Overall Summary Score (KCCQ-OSS) and independent parameters such as demographics, ejection fraction (EF), and other KCCQ-related variables as predictors of outcome in the study population.

Our findings on the association of dapagliflozin with improvements across all individual KCCQ components contribute to a more detailed understanding of previously reported benefits with SGLT-2 inhibitors on aggregated summary scores of the KCCQ. 3,7 The mean 2.1-point improvement in KCCQ-OSS with dapagliflozin originally reported in DELIVER 3 ...

2020年11月1日 · In heart failure, the Kansas City Cardiomyopathy Questionnaire (KCCQ) has been qualified by the U.S. Food and Drug Administration as a Clinical Outcome Assessment and recommended as a...

2021年3月29日 · Researchers compare the NYHA class identifier with KCCQ-QS. The debate of the best classifying model for cardiology outcomes continues.

2021年3月25日 · After a 12-month follow-up of patients in the CHAMP-HF registry, Kansas City Cardiomyopathy Questionnaire Overall Summary Score (KCCQ-OS) was shown to be more prognostically accurate compared...

2021年2月23日 · Recommended threshold scores have been reported for poor, fair, good, and excellent levels of functioning on the KCCQ overall summary score (OSS): ≤25, >25 to 50, >50 to 75, and >75 to 100, respectively. 9 These quartile ranges were used successfully in drug trials such as EPHESUS 2 to predict clinical outcomes at 2 years. However, a ...

2021年2月23日 · A greater improvement in KCCQ-OSS was observed among patients with a recent episode of worsening HF compared to those with chronic stable HF.

2021年9月1日 · We leveraged 3 clinical trials and a prospective cohort study to compare the validity, prognostic association, test-retest and internal reliability, responsiveness and interpretability in both HFrEF and HFpEF populations.