Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19.

KLF2 knockout (KO) T cells aberrantly acquired distinct features of exhaustion during acute LCMV infection. This included impaired effector and memory differentiation and function during both …

2025年1月2日 · KLF2 was required to suppress the exhaustion-promoting TF TOX and to enable the TF TBET to drive effector differentiation. KLF2 was also necessary to maintain a …

2024年12月25日 · Complete information for KLF2 gene (Protein Coding), KLF Transcription Factor 2, including: function, proteins, disorders, pathways, orthologs, and expression.

Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this review, we …

This study provides the first evidence that transcription factor KLF2 serves as a negative regulator of cardiac hypertrophy. Our findings highlight the therapeutic potential of enhancing KLF2 …

2025年2月9日 · KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling. KLF2 inhibits cancer cell migration and …

2025年2月1日 · Targeting KLF2 may represent a novel therapeutic approach against cardiac hypertrophy. Given the inhibitory effect of KLF2 on cardiac hypertrophy, it is imperative to …

2014年6月5日 · Klf2 is critical for ground state pluripotency. Klf2 is negatively regulated by Mek/Erk signaling at the posttranslational level. Erk2 directly interacts with and phosphorylates …

2021年10月13日 · Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this …