2024年12月25日 · KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11) is a Protein Coding gene. Diseases associated with KCNJ11 include Diabetes Mellitus, Permanent …

KCNJ11 gene mutations that cause permanent neonatal diabetes mellitus change single amino acids in the protein sequence. These mutations result in K-ATP channels that do not close, …

近期，一项大型国际队列研究对服用大剂量磺脲类药物治疗kcnj11突变所致pndm患者的长期应用价值进行了揭秘，该研究涉及欧洲五国，共纳入81‌例患者，转为磺脲类药物治疗时的年龄 …

2022年12月1日 · Here, we examined the association of common variants of KCNJ11 with type 2 diabetes incidence in the Iranian cohort, followed by carrying out the most comprehensive …

KCNJ11 mutations are rare in patients diagnosed with type 1 diabetes, the identification of a KCNJ11 mutation may have important treatment implications. mutations in KCNJ11 are the …

钾内向整流通道亚家族 J 成员 11： 钾通道存在于大多数哺乳动物细胞中，它们参与广泛的生理反应。该基因编码的蛋白是一种完整的膜蛋白和内向整流型钾通道。编码的蛋白质更倾向于让钾 …

The gene encoding the channel is called KCNJ11 and mutations in this gene are associated with congenital hyperinsulinism. [6]

迄今为止，具有显性突变的患者的表型似乎与具有隐性突变的患者的表型不同，因为大多数患者对二氮嗪治疗有反应。这些显性的abcc8或kcnj11基因突变在成年后是否易患糖尿病方面存在争 …

2017年6月6日 · KCNJ11 and ABCC8 encode the K ir 6.2 (pore-forming subunit) and SUR1 (regulatory subunit that binds to sulfonylurea) of pancreatic β cell K ATP channel respectively …

Numerous studies have reported the involvement of single nucleotide polymorphisms of the KCNJ11 gene and their interactions in the susceptibility to DM. This review discusses the …