2024年12月25日 · JUNB (JunB Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUNB include Small Cell Carcinoma and Anaplastic Large Cell Lymphoma. Among its related pathways are IL-1 Family Signaling Pathways and Gene expression (Transcription).

2024年9月11日 · JUNB蛋白是AP-1（Activator Protein-1）转录因子家族的重要成员，通过与其他A P-1家族成员形成异二聚体，JUNB参与调控多种细胞活动，包括细胞增殖、分化、 应激反应和凋亡。

Transcription factor jun-B is a protein that, in humans, is encoded by the JUNB gene. [5] [6] Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.

2022年12月9日 · The roles of JUNB in the control of cell division and tumorigenic processes are acknowledged but still unclear. Here, we report the results of combined transcriptomic, genomic, and functional studies showing that JUNB promotes cell cycle progression via induction of cyclin E1 and repression of transforming growth factor (TGF)-β2 genes.

Jun B proto-oncogene (JunB) is a crucial member of dimeric activator protein-1 (AP-1) complex, which plays a significant role in various physiological processes, such as placental formation, cardiovascular development, myelopoiesis, angiogenesis, endochondral ossification and epidermis tissue homeostasis.

2023年9月4日 · Jun B proto-oncogene (JunB) is a crucial member of dimeric activator protein-1 (AP-1) complex, which plays a significant role in various physiological processes, such as placental formation, cardiovascular development, myelopoiesis, angiogenesis, endochondral ossification and epidermis tissue homeos …

2022年6月8日 · 这项研究揭示了人类hpc分化过程中的表观遗传调控机制，发现了hec和hpc生成过程中新的调控因子junb。 同时，体内外HEC群体单细胞转录组对比分析为在体外更高效地获取高质量的HPC提供了重要的线索。

2024年1月9日 · 特异性敲除产热脂肪细胞JunB或消除脂肪中表达JunB的脂肪细胞均能促进能量代谢、改善能量平衡，从而预防和治疗肥胖及其胰岛素抵抗。 JunB的异常诱导是肥胖过程中形成更多低产热脂肪细胞和BAT功能受损的一个检查点，也是脂肪细胞异质性重组的重要机制。

junb（junb原癌基因，ap-1转录因子亚基）是一种蛋白质编码基因。 与JUNB相关的疾病包括原发性皮肤T细胞淋巴瘤和 间变性大细胞淋巴瘤 。 它的相关途径包括NK细胞中DAP12受体的免疫应答作用和Sertoli-Sertoli细胞连接动力学。

2019年7月8日 · Here we show that mice lacking JunB in CD4 + T cells (Junbfl/flCd4-Cre mice) were more susceptible to dextran sulfate sodium (DSS)-induced colitis because of impaired development of regulatory T...