JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines.

JH1 is the kinase domain important for the enzymatic activity of the JAK and contains typical features of a tyrosine kinase such as conserved tyrosines necessary for JAK activation (e.g., …

2024年12月25日 · This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The …

2021年11月26日 · In liver fibrosis, JAK1 is a constitutive TGFβRI-binding protein; thus, STAT3 is activated directly through JAK1 within minutes of TGFβ stimulation in a SMAD-independent …

tyrosine-protein kinase JAK1. The Janus kinase 1 is critical for pancreatic cancer initiation and progression. Individuals with JAK1 variants are affected by syndromic features encompassing …

We used JAK-deficient cell-lines and structure-based mutagenesis to study the function of JAK1 and its pseudokinase domain (JH2) in cytokine signaling pathways that employ JAK1 with …

2024年2月20日 · This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The …

2018年11月27日 · Given that IL-13 recruits several members of the Janus Kinase family (JAK1, JAK2, and TYK2) to its receptor complex, JAK inhibition may offer an alternate small molecule …

The valine residue at amino acid 658 in JAK1 is functionally equivalent to V617 in JAK2 ; i.e., it is critically important for negative regulation of JAK kinase activity. To our knowledge, JAK1 …

2018年11月20日 · Using a breast cancer model that conditionally lacks Janus kinase 1, we show here that JAK1 is essential for IL-6-class inflammatory cytokine signaling and plays a critical …