IOX1, 5-Carboxy-8-hydroxyquinoline, is a potent broad‐spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and …

2021年4月23日 · IOX1 effectively downregulates tumour PD-L1 expression in vitro and in vivo. Simultaneously, it inhibits cancer cell’s multidrug resistance and promotes intracellular DOX …

We also identified that IOX1, a known histone demethylase inhibitor, significantly suppresses Wnt target gene transcription and CRC tumorigenesis. Mechanistically, IOX1 inhibits the enzymatic …

IOX1 was the most potent inhibitor against 8 of the 10 tested KDMs. IOX1 exhibited IC 50 values at 1 μM or lower against the KDM3, KDM4 and KDM6 subfamilies, and 5-25 μM against the …

2021年4月23日 · Here, we report a histone demethylase inhibitor, 5-carboxy-8-hydroxyquinoline (IOX1), which inhibits tumour histone demethylase Jumonji domain-containing 1A (JMJD1A) …

IOX1 a broad-spectrum, cell permeable inhibitor of most 2OG oxygenases which does not require application in a pro-drug form [2]. It was discovered following a high throughput screening …

IOX1 (5-Carboxy-8-hydroxyquinoline) is a broad spectrum inhibitor of 2-oxoglutarate (2OG) oxygenases, including Jumonji C domain (JmjC) demethylases. It is useful for the study of …

The inhibition of JMJD2A by IOX1 suppressed the Ang II-induced cell proliferation, migration and cell cycle progression by inhibiting cyclin D1 expression and increasing p21 expression. The …

2024年11月15日 · IOX1 is the most potent broad-spectrum inhibitor of the 2-ketoglutarate (2OG), and its potential targets include a variety of histone demethylases and DNA demethylases, …