Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. [5] In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine.

Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions.

2021年3月29日 · Interleukin-6 (IL-6) is an endogenous chemical that is active in inflammation and in B cell maturation. Image Credit: StudioMoleKuul / Shutterstock.com. Besides being an immune protein,...

Interleukin 6 (IL-6) is a pleiotropic cytokine executing a diverse number of functions, ranging from its effects on acute phase reactant pathways, B and T lymphocytes, blood brain barrier permeability, synovial inflammation, hematopoiesis, and embryonic development.

Interleukin-6 (IL-6) is considered one of the most prominent pro-inflammatory cytokines 1. Blockade of IL-6 by the neutralising monoclonal antibody tocilizumab has been approved in more than 100 countries for the treatment of patients with …

Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the expression of a variety of proteins responsible for acute inflammation, and plays an important role in the proliferation and differentiation of cells in humans.

2024年12月25日 · IL6 (Interleukin 6) is a Protein Coding gene. Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and …

Several studies have shown that interleukin 6 (IL-6) is a multifunctional cytokine with both pro-inflammatory and anti-inflammatory activity, depending on the immune response context.

2006年7月28日 · Interleukin (IL)-6 is produced at the site of inflammation and plays a key role in the acute phase response as defined by a variety of clinical and biological features such as the production of acute phase proteins.

Interleukin-6 (IL-6) is a major cytokine that promotes anti- and pro-inflammatory outcomes by activating the membrane IL-6 receptor (IL-6R) or the soluble IL-6 receptor (sIL-6R). IL-6R and sIL-6R signaling engage the JAK1/2/3 targets and the downstream transcription of …