The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in …

Lipopolysaccharide-induced interleukin (IL)-4 receptor-alpha expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice. Brain, …

Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells, but this …

2022年8月22日 · Interleukin-4 (IL-4) CD4+T cells (Th2) synthesize IL-4, and it acts on both B and T cells. It is a B-cell growth factor and causes IgE and IgG1 isotype selection. It causes Th2 …

Keywords: alternative splicing, interelukin-4 receptor, interleukin-4 signaling, alternative macrophage activation. Abstract. Studies of IL-4 have revealed a wealth of information on the …

Interleukin (IL)-4 and IL-13 control the phenotype of a variety of cells in health and disease. Their receptor system, signaling cascades, and functional properties have gained clarity in the past …

2005年7月19日 · Interleukin-4 (IL-4) is a cytokine produced by T(H)2 type helper T cells and by mast cells, basophils, and eosinophils. This cytokine can elicit many responses, some of which …

Interleukin 4 (IL-4) is a pleiotropic type I cytokine that controls both growth and differentiation among haemopoietic and non-haemopoietic cells. Its receptor is a heterodimer. One chain, the …

Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor complex …

2025年1月1日 · IL-4 triggers the activation of the insulin receptor substrate 2 (IRS-2) signaling pathway by binding to interleukin receptors on the surface of macrophages, which enhances …