2021年2月2日 · Recent studies suggest that mitochondria can be transferred between cells to support the survival of metabolically compromised cells. However, whether intercellular mitochondria transfer occurs in white adipose tissue (WAT) or regulates metabolic homeostasis in vivo remains unknown.

2024年9月13日 · Transfer of mitochondria via nanotubes from bone marrow stem cells to CD8+ T cells augments cellular metabolism, empowering engineered T cells and tumor-infiltrating lymphocytes to counteract exhaustion and fight tumors more effectively.

2021年2月16日 · Under stress, increased ROS was shown to induce mitochondrial fission and perinuclear clustering of the resulting punctate mitochondria for subsequent mitochondrial extrusion and...

2023年11月8日 · In this Review, we describe the mechanisms by which mitochondria are transferred between cells and discuss how intercellular mitochondria transfer regulates the physiology and function of...

2021年2月16日 · Besides restoring stressed cells and damaged tissues due to mitochondrial dysfunction, the intercellular mitochondrial transfer also occurs under physiological conditions. In this review, the phenomenon of mitochondrial transfer is described according to its function under both physiological and pathological conditions, including tissue ...

2023年10月18日 · Several tools have been used to track the intercellular movement of mitochondria, including mitochondrial dyes, sequence variants in mtDNA and genetically encoded fluorescent proteins or tags.

2020年12月4日 · Genetic disruption of mitochondria uptake by macrophages reduces energy expenditure and exacerbates diet-induced obesity in mice, indicating that intercellular mitochondria transfer to macrophages mediates systemic metabolic homeostasis.

2024年11月14日 · Here, we describe an innovative platform to supply exogenous mitochondria to T cells, overcoming these limitations. We found that bone marrow stromal cells establish nanotubular connections with T cells and leverage these intercellular highways to transplant stromal cell mitochondria into CD8 + T cells. Optimal mitochondrial transfer required ...

2015年5月10日 · Recently described phenomenon of intercellular transfer of mitochondria attracts the attention of researchers in both fundamental science and translational medicine. In particular, the transfer of mitochondria results in the initiation of stem cell differentiation, in reprogramming of differentiated cells, and in the recovery of the lost ...

2024年9月5日 · This review introduces the principal approaches to intercellular mitochondrial transfer and examines its role in various diseases. Furthermore, we provide a comprehensive overview of the inhibitors and activators of intercellular mitochondrial transfer, offering a unique perspective to illustrate the relationship between intercellular ...