2023年4月4日 · DoD IL4 overview. The Defense Information Systems Agency (DISA) is an agency of the US Department of Defense (DoD) that is responsible for developing and …

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in …

2024年12月25日 · IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway …

STAT6 is so vital for the actions of IL-4 that Stat6-deficient mice phenocopy many of the defects observed with Il4- or Il4ra-deficient mice (e.g., related to Th2 differentiation and Ig class switch).

2021年9月7日 · Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells, …

IL-4 plays important roles in a myriad of cellular events, making it difficult to study its effects, particularly in vivo, on any one system. Although this review focuses on its neurological …

2025年2月8日 · IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway …

IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. …

2003年7月1日 · Acute expression of the IL4 gene by differentiated T H 2 cells is regulated by many positive and negative inducible transcription factors, such as nuclear factor of activated …

2024年12月10日 · IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway …

2025年2月7日 · Production of interleukin-4 (IL-4) results in the expansion of virtual memory CD8 T cells (T VM cells), which acquire a memory phenotype even in the absence of foreign antigen …

2020年3月6日 · A single Il4/Il13-related gene was found in spotted gar (Lepisosteus oculatus), an example of a bony fish that only went through two rounds of WGD, whereas two Il4/Il13 …

2012年11月1日 · IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions …

2020年8月10日 · IL-4 has been called the "prototypic immunoregulatory cytokine." Like many cytokines, it can affect a variety of target cells in multiple ways. IL-4 has an important role in …

Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor complex …

Interleukin-4 (IL4) is a growth factor for both B and T lymphocytes. - High levels of IL4Rs have been observed on tumors derived from such cells. - IL4Rs are also overexpressed on …

Role of IL-4 in Cardiovascular Diseases. Interleukin 4, a typical Th2 cytokine, 41 promotes tissue fibrosis in diseases involving the lung, 42 skin, 3 and liver. 43 Inhibition of tissue fibrotic …

Abstract Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor …

The IL-4R is composed of two transmembrane proteins. IL-4Rα chain (red) binds IL-4 (blue) with high affinity, leading to dimerization with γ c (yellow) or IL-13Rα1 (green), forming the type I or …

2012年11月1日 · IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions …

SNPs in IL4, IL13 and the receptor subunits are reportedly associated with glioma (111, 112). These polymorphisms highlight key features of IL-4/-13 receptor signaling that regulate …