Interleukin 32 (IL-32) is a pro-inflammatory cytokine that can induce cells of the immune system (such as monocytes and macrophages) to secrete inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and IL-6. In addition, it can also induce the production of chemokines such as IL-8 and MIP-2 / CXCL2. [6]

2024年12月25日 · IL32 (Interleukin 32) is a Protein Coding gene. Diseases associated with IL32 include Granulomatosis With Polyangiitis and Pancreatic Cancer. Among its related pathways are Signaling by Rho GTPases and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include cytokine activity.

2024年4月7日 · Interleukin 32 (IL32) is a pro-inflammatory cytokine that plays a key role in promoting sterile inflammation by modulating immune responses. However, the role of IL32 in various cancers remains...

2024年9月6日 · IL-32对肿瘤的发生、侵袭及迁移也有重要的影响，其作用的差异可能与IL-32的亚型及复杂的肿瘤微环境差异相关。 此文旨在阐释IL-32在炎症和肿瘤中的作用及相关机制。 正文. IL可协同其他细胞因子组成功能复杂的调控网络，在机体的信息传递、免疫调节中发挥重要作用。 IL-32是IL家族的一员，其9个亚型的大小和结构存在不同程度的差异，在炎性疾病和恶性肿瘤中发挥不同的功能。 研究发现，在不同情况下，IL-32既能促炎也能抑炎，既有促癌也有抑癌作用 …

2020年9月20日 · 白细胞介素⁃32 （Interleukin⁃32， IL⁃32） 作为新近发现的促炎症细胞因子， 可参与炎症性疾病和多种恶性肿瘤的发展。 本文就IL⁃32在恶性肿瘤中的研究进展予以综述。 1992年， Dahl等[3] 首次发现IL⁃32， 因其转录本可在丝裂原活化的T细胞以及IL⁃2活化的自然杀伤 细胞 （natural killer cell， NK cell） 中表达增加， 故命名 为NK4蛋白； 2005年， Kim等[4] 进行生物芯片技术研 究时， 发现NK4蛋白具有典型的细胞因子活性， 并 在炎症中发挥重要作用， 遂 …

2021年9月1日 · Interleukin 32 is a unique intracellular cytokine which affects many cellular and physiological functions like cell death and survival, inflammation and response to pathogens. With numerous transcripts, more than one biologically active isoforms, IL32 drives its effect in diverse cellular functions.

Interleukin 32 (IL32) is a pro‐inflammatory cytokine that plays a key role in promoting sterile inflammation by modulating immune responses. However, the role of IL32 in...

Interleukin-32 (IL-32) is a novel cytokine involved in inflammation and cancer development. IL-32 gene consists of eight small exons, and IL-32 mRNA has nine alternative spliced isoforms, and was thought to be secreted because it contains an internal signal sequence and lacks a transmembrane region.

Interleukin-32 (IL-32), a recently described novel proinflammatory cytokine primarily expressed by natural killer (NK) cells, monocytes, epithelial cell lines, and T-cells, has gained popularity because of its involvement in many crucial biological phenomena [3 – 6].

2017年9月3日 · IL-32 是一种新的促炎性细胞因子，在人和小鼠细胞内通过 NF-B 和蛋白激酶 P38MAPK 信号途径激活多种炎症因子（如 TNF,IL-1，IL-6 等）和趋化因子的表达。 临床研究显示 IL-32 在许多慢性炎症性疾病如类风湿性关节炎，炎性肠病中起重要作用，而 IL-32 是其最活跃的亚型。 在类风湿性关节炎纤维样滑膜细胞中 IL-32 经 TNF-α和 poly;c 刺激后其 mRNA 水平升高，但无蛋白分泌，而 Shioya 等，却发现某些上皮细胞可分泌 IL-32 蛋白，这可能于细胞的类型有 …