OriGene Anti-IL1F6 Monoclonal (OTI3A12), TrueMAB™, Catalog # TA501427. Tested in Western Blot (WB) and Immunocytochemistry (ICC/IF) applications. This antibody reacts with Human samples. Supplied as 100 µL purified antibody (0.42 mg/mL).

Interleukin-36 alpha also known as interleukin-1 family member 6 (IL1F6) is a protein that in humans is encoded by the IL36A gene. [5] [6]

Homo sapiens gene IL1F6, encoding interleukin 1 family, member 6 (epsilon). RefSeq annotates one representative transcript. According to AceView, this gene is expressed at low level, only 4.6% of the average gene in this release. The sequence of this gene is defined by 6 GenBank accessions, some from esophagus (seen 2 times).

2021年8月27日 · 人和小鼠的基因组编码四个il-36基因，il1f6（编码il-36a）、il1f8（编码il-36β）、il1f9（编码il-36𝜸）以及il1f5（编码il-36ra），与il-36r受体结合发挥功能。 其中前三个属于激动剂激活MyD88依赖的信号通路，而IL-36Ra竞争性地与IL-36R结合抑制其招募IL-1RAcP受体，阻 …

Anti-IL1F6 mouse monoclonal antibody (BD-PE3590) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IL1F6 . HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY …

2018年7月1日 · IL-36α (gene symbol Il1f6), a member of the IL-36 family, is closely associated with inflammatory diseases, including colitis and psoriasis. In this study, we found that Il1f6 -/- mice developed milder psoriasiform dermatitis upon treatment with imiquimod, a ligand for TLR ligand 7 (TLR7) and TLR8, whereas Il1f6 -/- mice showed similar ...

2017年10月23日 · IL-1 family member 6 (IL-1F6, also known as IL-36α) is overexpressed in injured DTs from various mouse kidney diseases, including lupus nephritis, diabetic nephropathy, and traumatic kidney injury (8 – 10). Therefore, IL-36α could be a useful marker of DT injury; however, its pathological function remains unclear. in vitro.

Know comprehensive IL-36 alpha/IL-1F6 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

In cultured monocytes up-regulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by up-regulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation.

IL-36 alpha (IL-1F6) 是 IL-36 家族的其中一个亚型，属于 IL-1 超家族。 IL-36 alpha 介导炎症反应。 IL-36 alpha 与 IL-36R 结合并激活 NF-κB 和 MAPK 信号通路，但这种激活需要中性粒细胞来源的蛋白酶对 IL-36 alpha 的 N 端进行切割。 IL-36 alpha 还可以结合 IL-1Rrp2 并募集 IL-1RAcP。 IL-36 alpha 通过 IL-36R/IL-1RAcP 激活 MAPK、Erk1/2 和 JNK 信号通路。 IL-36 alpha/IL-1F6 蛋白, Human (153a.a) 是一种由 E. coli 产生的重组人 IL-36 alpha (K6-F158)，不带任何标签。