2024年12月25日 · IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. Diseases associated with IL17RB include Herpes Zoster and Parasitic Helminthiasis Infectious Disease. Among its related pathways are IL-17 Family Signaling Pathways and Cytokine Signaling in Immune system.

Interleukin-17 receptor B is a protein that in humans is encoded by the IL17RB gene. [5][6][7] The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17 (A) or IL17C.

il-17rb（白细胞介素17 受体 b）是一种由 il17rb 基因编码的蛋白质，是促炎细胞因子 il-17b 和 il-17e 的受体。il-17rb 在肾脏、胰腺、肝脏、大脑和肠道中的表达较高。il-17rb 可能在造血细胞分化和生长中发挥作用。il-17rb 与炎症性疾病和癌症有关。

2020年4月21日 · In mouse models, IL-17B signaling through IL-17RB directly promotes cancer cell survival, proliferation, and migration, and induces resistance to conventional chemotherapeutic agents.

2025年3月12日 · Supraoptimal ILC2 stimulation by IL-25 resulting from tuft cell Il17rb deficiency or prolonged succinate exposure induces a state of hypoproliferation in ILC2s, also observed in chronic helminth ...

2025年2月8日 · High IL17RB expression is associated with breast cancer. Results show that amplified signaling of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B promot tumorigenicity in breast cancer cells and impeded acinus formation in immortalized normal mammary epithelial cells.

2021年10月17日 · IL-17RB enhances thyroid cancer cell invasion and metastasis via ERK1/2 pathway-mediated MMP-9 expression. Ren L, et al. Mol Immunol, 2017 Oct. PMID 28715683. What's a GeneRIF? IL17RB expression is associated with malignant cancer behaviors and poor prognosis in oral cancer.

2022年10月25日 · Upregulation of interleukin-17 receptor B (IL-17RB) is known to be oncogenic, while other IL-17 receptors and ligands are generally involved in pro-inflammatory pathways. We identify a mouse neutralizing monoclonal antibody (mAb) D9, which blocks the IL-17RB/IL-17B pathway and inhibits pancreatic tumorigenesis in an orthotopic mouse model.

2019年6月10日 · IL17RB was distinctively expressed by Dclk1 + mouse intestinal tumor cells. Using Il17rb-CreERT2-IRES-EGFP mice, we show that IL17RB marked intestinal TSCs in an IL13-dependent manner. Tuft cell-like cancer cells were detected in a subset of hCRCs.

2025年3月1日 · The IL-17B/IL-17RB oncogenic signaling axis promotes pancreatic cancer progression through interaction with mixed-lineage kinase 4 (MLK4). Here, we improved the effectiveness of a therapeutic peptide (TAT-IL17RB 403–416, loop peptide) that