2019年11月19日 · In their Review, Barata, Durum and Seddon describe IL-7’s key homeostatic functions and how its dysregulation can lead to autoinflammatory disease and cancer.

2002年6月1日 · IL-7 can be identified within the thymus of 13-day murine embryos coincident with the first wave of thymocyte expansion.19 The production of IL-7 has been identified in a subset of MHC class II+ epithelial cells21 that also express SCF, another important growth factor for early thymocytes.92 Interestingly, SCF synergizes with IL-7 in thymocyte ...

2021年12月1日 · Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B cells, remains one of the most extensively studied cytokines. It ...

Overview: IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind Type I cytokine receptors. It is produced by stromal cells and is required for development and homeostatic survival of lymphoid cells.

In this review, we focus on the emerging details on the developmentally regulated spatial distribution of IL-7 in vivo that controls all IL-7 receptor (IL-7R) expressing cell subsets with tissue specific and systemic functions in immunity, with a particular emphasis on …

2011年4月21日 · Interleukin-7 (IL-7) induces T cell proliferation and enhances antigen-specific immune responses: attributes that pinpoint its value as a potential therapeutic agent.

Interleukin-7 (IL-7) is a non-hematopoietic cell-derived cytokine with a central role in the adaptive immune system. It promotes lymphocyte development in the thymus and maintains survival of naive and memory T cell homeostasis in the periphery. ...

2022年12月1日 · IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind Type I cytokine receptors. It is produced by stromal cells and is required for development and homeostatic survival of lymphoid cells.

2022年12月1日 · IL-7, originally termed “lymphopoietin-1” (LP-1), was first identified as a pre-B-cell growth factor produced by bone marrow stromal cells [63], [64]. Further studies identified VCAM-1 + reticular stromal cells and mesenchymal progenitors as producers of IL-7 in bone marrow [65], [66], [67].

IL-7’s essential properties as a required factor for lymphocyte development and modulator of T cell homeostasis make it an attractive candidate for modulating immunodeficiency and augmenting immune based therapies, but also render it a plausible culprit in human disease.