
Interleukin 24 - Wikipedia
Interleukin 24 (IL-24) is a protein in the interleukin family, a type of cytokine signaling molecule in the immune system. In humans, this protein is encoded by the IL24 gene. IL-24 is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1 / IL-20R2 and IL-22R1/IL-20R2.
白细胞介素-24(IL-24) - 丁香通研选
2017年9月1日 · IL-24(白细胞介素-24)又名黑色素瘤分化相关基因 7(mda-7),是一个既能抑制肿瘤细胞生长和血管生成并诱导凋亡,同时又能诱导免疫细胞表达细胞因子的新型抑癌基因。 主要由具有免疫活性的细胞分泌。 能刺激促炎症因子产生,参与免疫活化。 IL- 24 基因定位于 1 号染色体的 1q32.2- 1q41 位点,是一个单拷贝基因,有 7 个外显子和 6 个内含子,由 7 025 个 kb 组成,其 cDNA 全长 1 718 个 kb,其中包含一个促进分泌的片段。 人 IL- 24 蛋白由 206 个氨基 …
IL-24: A new player in the pathogenesis of pro-inflammatory and ...
2020年7月1日 · In this review, we show recent advances in the basic characteristics of IL-24 and its novel functions in the pathogenesis of allergic skin inflammation, focusing on AD. A better understanding of the role of IL-24 in allergic diseases can lead to the development of new therapeutic options.
IL-24: A new player in the pathogenesis of pro-inflammatory and ...
Interleukin (IL)-24 is a member of the IL-20 family of cytokines and is produced by various types of cells, such as CD4 + T cells, NK cells, mast cells, keratinocytes, bronchial epithelial cells, and myofibroblasts. Previous studies suggest that IL-24 plays an essential role in the pathogenesis of pro-inflammatory autoimmune disorders such as ...
Interleukin-24 Immunobiology and Its Roles in Inflammatory
2022年1月6日 · Interleukin (IL)-24 belongs to the IL-10 family and signals through two receptor complexes, i.e., IL-20RA/IL-20RB and IL-20RB/IL22RA1. It is a multifunctional cytokine that can regulate immune response, tissue homeostasis, host defense, and oncogenesis. Elevation of IL-24 is associated with chronic …
IL24 Gene - GeneCards | IL24 Protein | IL24 Antibody
2024年12月25日 · IL24 (Interleukin 24) is a Protein Coding gene. Diseases associated with IL24 include Melanoma and Lower Gum Cancer. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL20.
多功能抗癌基因白细胞介素24在肿瘤中的研究进展 - 肿瘤研究与临床
白细胞介素24 (IL-24)是通过消减杂交法从人黑色素瘤细胞中分离出来的黑色素瘤分化相关基因,属于IL-10家族,它有促进肿瘤细胞凋亡、抑制血管形成、增强放化疗敏感性以及免疫调节等作用,而对正常细胞没有毒副作用。 作为一种具有多种抗肿瘤途径的细胞因子,IL-24将成为肿瘤基因治疗的新模式。 文章主要对IL-24在抗肿瘤治疗中的作用及其机制作一综述。 引用本文: 姜增誉, 侯文娜, 何生. 多功能抗癌基因白细胞介素24在肿瘤中的研究进展 [J] . 肿瘤研究与临床, 2016, 28 (2) : …
IL-24在湿疹与过敏性炎症中的成药潜力:抗体靶点与蛋白结构解析 …
IL-24( 白细胞介素-24 )是一个近年来在特异性皮炎( Atopic Dermatitis skin,AD)及过敏性炎症中被证实具有重要作用的细胞因子。研究表明,IL-24通过激活 JAK-STAT信号通路 ,IL-24通过上调 角质形成细胞 中的促炎性因子如IL-33,从而加重湿疹样的皮肤病变。本文从IL-24 ...
白细胞介素-24 (IL-24) | 重组蛋白 | MCE - MCE-生物活性 ...
白介素 24 (IL-24) 属于细胞因子 IL10 家族,可选择性诱导癌细胞凋亡,并在黑色素瘤细胞分化过程中被识别。 IL-24 过表达会增加 GADD 家族基因的表达并诱导细胞凋亡。 IL-24 Protein, Human (HEK293, His) 是重组的 IL-24 蛋白,由 HEK293 表达,带有 C-10*His 标签。 IL-24 蛋白由 T 细胞产生,调节免疫反应、组织稳态、防御和肿瘤发生。 它在流感感染中诱导 I 型干扰素反应,通过 IL20RA/IL20RB 或 IL20RB/IL22RA1 受体复合物发出信号,刺激 JAK1-STAT3 和 MAPK 通路 …
Interleukin (IL)-24: Reconfiguring the Tumor Microenvironment …
However, the ability of IL-24 treatment on modulating the tumor microenvironment and immune response is underinvestigated. In this article, we summarize the biological and functional properties of IL-24 and the benefits of applying IL-24-based therapy for cancer.