Zinc finger protein Helios is a protein that in humans is encoded by the IKZF2 gene. [ 5 ] [ 6 ] [ 7 ] This protein is a member of Ikaros family of transcription factors. [ 8 ]

2024年12月25日 · IKZF2 (IKAROS Family Zinc Finger 2) is a Protein Coding gene. Diseases associated with IKZF2 include Otitis Media and Leukemia, Acute Lymphoblastic . Gene Ontology (GO) annotations related to this gene include nucleic acid …

2023年3月3日 · The IKZF2 (Helios) transcription factor plays a crucial role in maintaining function and stability of Treg cells, and IKZF2 deficiency reduces tumor growth in mice. Here we report the discovery of NVP-DKY709, a selective molecular glue degrader of IKZF2 that spares IKZF1/3.

2019年1月3日 · IKZF2 is highly expressed in leukemic stem cells (LSCs), and its deficiency results in defective LSC function. IKZF2 depletion in acute myeloid leukemia (AML) cells reduced colony formation, increased differentiation and apoptosis, and delayed leukemogenesis.

2025年2月8日 · Identification of germline monoallelic mutations in IKZF2 in patients with immune dysregulation. Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells. Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity.

This study, based on a large clinical cohort, found that IKZF2, an essential transcription factor during T cell development and differentiation, showed stage-dependent overexpression in the malignant T cells in mycosis fungoides lesions.

2018年11月21日 · Here we identify Ikzf2 (which encodes Helios) as an essential transcription factor in mice that is required for OHC functional maturation and hearing. Helios is expressed in postnatal mouse OHCs,...

2023年4月10日 · Degradation of IKZF2 and CK1α blocks cell growth and induces myeloid differentiation in AML cells through CK1α-p53- and IKZF2-dependent pathways. Target degradation by DEG-35 or a more soluble analog, DEG-77, delays leukemia progression in murine and human AML mouse models.

2022年4月12日 · We identified germline IKZF2 mutations (one nonsense (p.R291X)- and 4 distinct missense variants) in six patients with systemic lupus erythematosus, immune thrombocytopenia or EBV-associated hemophagocytic lymphohistiocytosis.

2021年11月26日 · Here, we describe a heterozygous IKZF2 loss-of-function variant in a single family, causing an immunodeficiency with increased immune activation and profound reduction of mucosal-associated invariant T (MAIT) cells. Affected patients have lymphadenopathy with dysregulated germinal centers and aberrations in antibody production, reminiscent of ...