2024年12月25日 · IGFBP5 (Insulin Like Growth Factor Binding Protein 5) is a Protein Coding gene. Diseases associated with IGFBP5 include Insulin-Like Growth Factor I and Pulmonary Fibrosis . Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of ...

IGFBP-5 是 IGFBPs 家族中最保守的蛋白，且作为一个主要的调控因子调控细胞的生长和发育等过程。 以 IGF-IGFBP-ALS (acid labie subunit)三聚体形式存在于血液中，这种三聚体的作用是运输和延长 IGFs 的半衰期、调节血液中 IGFs 的浓度。 小鼠IGFBP-5 cDNA编码271个氨基酸 (aa)残基前体蛋白和19个aa残基信号肽，这些信号肽被加工成252个aa残基成熟蛋白。 到目前为止，IGFBP-5在所有研究过的脊椎动物中都有发现，它的同源氨基酸序列通常是所有IGFBP类型中氨基酸 …

Insulin-like growth factor-binding protein 5 (IBF-5) is a protein that in humans is encoded by the IGFBP5 gene. [5] An IGFBP5 gene was recently identified as being important for adaptation to varying water salinity in fish.

胰岛素样生长因子结合蛋白 5（insulin-like growth factor-binding protein 5， IGFBP5 ）是一种重要的分泌蛋白，属于IGFBP家族（IGFBP1～IGFBP7），其与多种组织中的炎症和纤维化有关[6-9]。研究发现IGFBP5在DKD中的表达显著上调。然而，IGFBP5在DKD中的功能及其机制尚不清楚。

本文将详细介绍igfbp5基因的功能、作用机制、信号通路及其与疾病的关系，帮助读者全面理解这一重要基因在生物学和医学中的作用。 igfbp5基因概述 igfbp5 ，即胰岛素样生长因子结合蛋白5，是胰岛素样生长因子结合蛋白家族的一员。

IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis. HLA-A, HSPA5, IGFBP5 and PSMA2 Are Restriction Factors for Zika Virus Growth in Astrocytic Cells. Insulin-like growth factor 5 associates with human Ass plaques and promotes cognitive impairment.

In this review, the focus lies on the biological effects and regulation of IGFBP5 in breast cancer. In breast cancer, estrogen is a critical regulator of IGFBP5 transcription. It exerts its effect through an intergenic enhancer loop that is part of the chromosomal breast cancer susceptibility region 2q35.

2016年2月8日 · Using a large-scale, unbiased quantitative proteomic platform, we comprehensively characterized the rapamycin-sensitive secretome in TSC2−/− mouse embryonic fibroblasts, and identified IGFBP5 as...

Title: IGFBP5 is released by senescent cells and is internalized by healthy cells, promoting their senescence through interaction with retinoic receptors. Secreted insulin-like growth factor binding protein 5 functions as a tumor suppressor and chemosensitizer through inhibiting insulin-like growth factor 1 receptor/protein kinase B pathway in ...

Enables insulin-like growth factor I binding activity. Involved in several processes, including cellular response to cAMP; regulation of smooth muscle cell migration; and regulation of smooth muscle cell proliferation. Part of insulin-like growth factor ternary complex.