Insulin-like growth factor binding protein, acid labile subunit, also known as IGFALS, is a protein which in humans is encoded by the IGFALS gene. [5]

2024年12月25日 · IGFALS (Insulin Like Growth Factor Binding Protein Acid Labile Subunit) is a Protein Coding gene. Diseases associated with IGFALS include Acid-Labile Subunit Deficiency and Short Stature Due To Primary Acid-Labile Subunit Deficiency.

2021年3月4日 · In this study, we found that IGFALS is virus inducible, while it in turn inhibits viral replication. Mechanistically, IGFALS directly associates with IRAK1 and TRAF6, facilitating IRAK1/TRAF6...

2025年2月8日 · Primary acid-labile subunit deficiency due to recessive IGFALS mutations results in postnatal growth deficit associated with low circulating insulin growth factor (IGF)-I, IGF binding protein-3 levels, and hyperinsulinemia.

A novel homozygous mutation in IGFALS, c.380T>C (p.L127P), was identified in two siblings of a consanguineous family. Heterozygous IGFALS gene variants could be responsible for short stature in a subset of idiopathic short stature children …

Acid-labile subunit (ALS) forms ternary complexes with insulin like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) and is essential for normal circulating IGF-1 levels. The IGFALS gene encodes the ALS and mutations in IGFALS cause ALS deficiency.

2014年8月25日 · Surprisingly, absence of Igfals did not affect glucose and insulin homeostasis. Therefore, Igfals is required for postnatal accumulation of IGF1 and IGFBP3 but, consistent with findings supporting a predominant role for locally produced IGF1, is not critical for growth.

2024年12月25日 · IGFALS overexpression inhibits proliferation, invasion, and migration of HCC cells in vivo and in vitro. IGFALS promotes the binding of PPAR-γ with USP9X, thereby facilitating the de-ubiquitination of PPAR-γ. IGFALS upregulates HMGCS2 expression and inhibits EMT by upregulating PPAR-γ protein levels.

Pharos is the web interface for data collected by the Illuminating the Druggable Genome initiative. Target, disease and ligand information are collected and displayed.

the Igfals gene has a role in skeletal response of male mice to anabolic hormone therapy; A modest reduction in post-natal growth in the null ALS mice and in the ALS-deficient patients was observed