Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. The MeSH definition reads: "A well-characterized neutral peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like and mitogenic activities.

胰岛素样生长因子2 (insulin-like growth factor 2，Igf2)基因是最早发现的内源性印迹基因，其表达、调控不遵循 孟德尔遗传规律。 Igf2是一种多功能 细胞增殖 调控因子，在细胞的分化，增殖、胚胎的生长发育以及肿瘤细胞增殖中具有重要的促进作用。 [1] 早在1913年，Carell等在研究组织和 器官移植 时发现某些组织和器官的提取物能够诱导细胞的增殖。 1963年，Froesch在人血清中发现了不能被 胰岛素抗体 所中和的胰岛素样 生长因子，并将其称为非抑制性胰岛素样活性。

igf受体分两型，即igf-Ⅰ受体（igf-Ⅰr）和igf-Ⅱ受体（igf-Ⅱr），前者属酪氨酸激酶型受体，是由两个α亚基组成异源四聚体糖蛋白；后者没有氨酸激酶活性。

2024年12月25日 · IGF2 (Insulin Like Growth Factor 2) is a Protein Coding gene. Diseases associated with IGF2 include Silver-Russell Syndrome 3 and Silver-Russell Syndrome 1. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

2022年6月1日 · IGF-2是胚胎生长发育因子，是妊娠期主要的促生长激素。 它还参与细胞增殖、生长、迁移、分化和存活的调节。 此外，IGF-2在多种看似无关的癌症如乳腺癌、结肠癌和肺癌等的发展中发挥作用。 以上是目前针对IGF-1和IGF-2比较公认的共识。 但是，该共识亟待更新与改进。 首先，我们来观察IGF-2和IGF-1的蛋白结构差异，两种胰岛素样生长因子的结构同源性在不同物种间均高度保守 [10] 。 组成IGF-1、IGF-2和胰岛素的氨基酸有45%是相同的，而IGF-1和IGF …

The insulin-like growth factor (IGF) system regulates metabolic and mitogenic signaling through an intricate network of related receptors and hormones. IGF-II is one of several hormones within this system that primarily regulates mitogenic functions ...

Insulin-like growth factor two (IGF-II) is a key protein regulating growth, particularly during normal fetal development, but it is also often dysregulated during tumorigenesis [1, 2, 3]. In this review, we focus on the role of IGF-II in physiological functions and …

The IGF2 gene provides instructions for making a protein called insulin-like growth factor 2. This protein plays an essential role in growth and development before birth. Studies suggest that insulin-like growth factor 2 promotes the growth and division (proliferation) of cells in many different tissues.

Insulin-like growth factor II (IGF-II) plays a key role in mammalian growth, influencing foetal cell division and differentiation and possibly metabolic regulation. The mature 67 amino acid peptide shares sequence homology with both insulin and IGF-I.

2019年10月6日 · The IGF-II gene is adjacent to the insulin gene, which is a result of gene duplication, but has evolved to be considerably more complicated. It was one of the first genes recognised to be imprinted and expressed in a parent-of-origin specific manner.