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This is a RESTful API for programmatic access to the IEU OpenGWAS database. The API is designed to support the following operations: Make available study information about all the GWAS datasets in the database; Obtain the top hits from a GWAS, with optional automatic clumping. Find any set of variant-trait associations based on rsid or ...

2020年8月10日 · Developed at the MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, this resource is a manually curated collection of complete GWAS summary datasets made available as open source files for download, or by querying a database of the complete data.

IEU OpenGWAS database 4.0.0 [ Base URL: /api ] /api/swagger.json. A RESTful API for querying tens of thousands of GWAS summary datasets. Authorize. ... Extract top hits based on p-value threshold from a GWAS dataset. POST /tophits. phewas. Perform PheWAS of specified variants across all available GWAS datasets. POST /phewas. POST /phewas /slow ...

2025年3月4日 · Perform fast queries in Python against a massive database of complete GWAS summary data. The IEU OpenGWAS database comprises over 50,000 curated, QC'd and harmonised complete GWAS summary datasets and can be queried using an API.

The OpenGWAS database comprises over 50,000 curated, QC'd and harmonised complete GWAS summary datasets and can be queried using an API. See here for documentation on the API itself. This R package is a wrapper to make generic calls to the API, plus convenience functions for specific queries.

The OpenGWAS database comprises over 50,000 curated, QC’d and harmonised complete GWAS summary datasets and can be queried using an API. See here for documentation on the API itself. This R package is a wrapper to make generic calls to the API, plus convenience functions for specific queries.

This R package provides fast and convenient functions for querying and creating GWAS summary data in GWAS VCF format. The package builds on the VariantAnnotation Bioconductor package, which itself is based on the widely used SummarizedExperiment Bioconductor package.

The MRC Integrative Epidemiology Unit (MRC IEU) at the University of Bristol hosts the IEU GWAS Database, the world’s largest collection of Genome Wide Associate Study data. As of April 2019, the database contains over 250 billion genetic association records from more than 20,000 analysis of human traits.

Complete GWAS summary datasets are now abundant. A large repository of curated, harmonised and QC'd datasets is available in the IEU GWAS database. They can be queried via the API directly, or through the ieugwasr R package, or the ieugwaspy python package.