ICAM-1 is a member of the immunoglobulin superfamily, the superfamily of proteins including antibodies and T-cell receptors. ICAM-1 is a transmembrane protein possessing an amino-terminus extracellular domain, a single transmembrane domain, and a carboxy-terminus cytoplasmic domain.

ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation. However, in addition to vascular endothelial cells, ICAM-1 expression is also robustly ...

2024年12月25日 · ICAM1 (Intercellular Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with ICAM1 include Malaria and Cerebral Malaria. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Cytokine Signaling in Immune system.

2023年8月1日 · ICAM-1, an immunoglobulin (Ig)-like cell adhesion molecule, is expressed by two cell types: leukocytes and endothelial cells. ICAM-1 expression is mainly controlled by transcription. ICAM-1 plays a vital role in inflammation and …

In their paper, Sumagin et al. have examined the role of ICAM-1 and the possible role of a leukocyte-endothelium interaction in the regulation of vascular permeability. During inflammation development, two major events occur.

ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis. Inactivation of ICAM1 inhibits metastasis and improves the prognosis of Ewing's sarcoma. Genome-wide identification of lncRNAs and mRNAs differentially expressed in human vascular smooth muscle cells stimulated by high phosphorus.

2014年5月15日 · ICAM-1 is an iconic marker of inflammation in EAE and multiple sclerosis, with elevated expression at lesion sites on endothelial cells and on infiltrating and resident CNS cells (7, 57, 58).

2021年12月1日 · Intracellular adhesion molecule 1 (ICAM-1) is one of the most extensively studied inducible cell adhesion molecule which is responsible for several immune functions. The molecule is constitutively expressed over the cell surface and is regulated up / down in response to inflammatory mediators.

ICAM-1 is a transmembrane, cell surface glycoprotein expressed by a variety of cells, but has been best-studied in vascular endothelium. Structurally, ICAM-1 is composed of five extracellular IgG- like domains to help facilitate cell-cell interactions and has a short cytoplasmic tail anchored to the cytoskeleton to facilitate intracellular ...

2023年8月1日 · Intercellular adhesion molecule 1 (ICAM-1) and Vascular cell adhesion molecule 1 (VCAM-1) belong to the immunoglobulin superfamily of cell adhesion molecules (CAM) with a crucial role in mediating the strong adherence of leukocytes to endothelial cells in numerous acute as well as chronic diseases.