2024年12月25日 · IFNAR1 (Interferon Alpha And Beta Receptor Subunit 1) is a Protein Coding gene. Diseases associated with IFNAR1 include Immunodeficiency 106 Viral Infections and Primary Immunodeficiency With Predisposition To Severe Viral Infection .

Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene. [5][6] The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for type I interferons, including interferon-alpha, -beta, and -lambda.

IFNAR is a heteromeric cell surface receptor composed of two subunits, referred to as the low affinity subunit, IFNAR1, and the high affinity subunit, IFNAR2. [7][8] Upon binding of type I interferons, IFNAR activates the JAK-STAT signalling pathway, along with MAPK, PI3K, and Akt signaling pathways. [2] .

2021年11月23日 · Type I interferons bind to cell surface receptors composed of the subunits IFNAR1 and IFNAR2, the intracellular domains (ICDs) of which are associated with the kinases TYK2 and JAK1, respectively.

2021年11月23日 · Type I interferons form a complex with the receptor subunits IFNAR1 and IFNAR2, which stimulates cross-activation of the tyrosine kinases associated with the receptor subunits, TYK2 and JAK1. This leads to tyrosine phosphorylation of the IFNARs and of the STAT proteins that mediate transcriptional responses.

Detection of interferon alpha and beta receptor subunit 1 (IFNAR1) loss-of-function Glu386 * variant by tri-allelic genotyping. Association of IFNAR1 and IFNAR2 with COVID-19 severity. CK1alpha upregulates the IFNAR1 expression to prompt the anti-HBV effect of type I IFN in hepatoma carcinoma cells.

2021年1月19日 · IFNAR1 is S-palmitoylated on the PM proximal Cys 463 residue. IFNAR1 cytosolic tail interacts with TYK2 kinase FERM and SH2 domains through a minimal region that corresponds to 486–511 residues (thick blue line).

2025年1月5日 · Title: CK1α upregulates the IFNAR1 expression to prompt the anti-HBV effect of type I IFN in hepatoma carcinoma cells.

2024年3月5日 · Correlation between IFNAR1 expression in peripheral blood T lymphocytes and inflammatory cytokines, tumor-infiltrating lymphocytes, and chemosensitivity in patients with colorectal cancer. A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in …

2023年9月25日 · As a ligand, the N-terminus of secreted LRPAP1 binds with the extracellular domain of IFNAR1 that triggers the receptor ubiquitination and degradation and promotes virus infection both in...