2024年12月25日 · HIF3A (Hypoxia Inducible Factor 3 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF3A include Subglottis Benign Neoplasm and Renal Cell Carcinoma. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Cellular responses to stimuli.

HIF1α and HIF2α are the best characterized and structurally similar isoforms, while HIF3α is the most distantly related and is less studied. The HIF3α gene undergoes complex regulation and produces a large number of long and short mRNA splice variants, which are translated into different polypeptides.

Hypoxia-inducible factor 3 alpha is a protein that in humans is encoded by the HIF3A gene. [5][6][7] The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia).

且与前2种不同的是HIF-3α有多种剪切体，如：老鼠中包括全长的鼠HIF-3α (mHIF-3α)，抑制性PAS结构域蛋白 (inhibitory PAS domain protein, IPAS)，新生儿和胚胎PAS蛋白 (neonatal and embryonic PAS protein, NEPAS) [2 - 4]，人体中的剪切体有hHIF-3α 1~10 [5 - 9]。...

HIF-3α在蛋白质结构和基因表达调控方面不同于HIF-1α和HIF-2α。 长期以来，HIF-3α被认为是HIF调控基因的负介体。 HIF-3具有转录调节功能，在缺氧期间通过与HIF-1α和HIF-2α竞争结合靶基因中的转录元件而对基因表达产生负面影响。 以前，已经确定了HIF-3α的某些靶基因，证实了HIF-3α作为转录因子的作用。 本文综述了HIF-3的蛋白结构，基因调控和生物学功能。 Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review).

2025年2月8日 · HIF3A is regulated by hypoxia in the developing human lung. Hypoxia upregulated transcription from all three alternative HIF-3alpha promoters. siRNA experiments showed that this induction is mediated specifically by HIF-1 and not by HIF-2.

由该基因编码的蛋白质是几种 alpha/beta 亚基异二聚体转录因子之一的 alpha-3 亚基，这些转录因子调节许多对低氧张力 (缺氧) 的适应性反应。 alpha-3 亚基缺少在包含 alpha-1 或 alpha-2 亚基的因子中发现的反式激活域。 人们认为含有 alpha-3 亚基的因子是缺氧诱导基因表达的负调节因子。 已发现该基因的多个选择性剪接转录物变体。 [RefSeq 提供，2011 年 3 月]

2015年10月28日 · HIF1α and HIF2α are the best characterized and structurally similar isoforms, while HIF3α is the most distantly related and is less studied. The HIF3α gene undergoes complex regulation and produces a large number of long and short mRNA splice variants, which are translated into different polypeptides.

2025年2月8日 · HIF-3α Promotes Metastatic Phenotypes in Pancreatic Cancer by Transcriptional Regulation of the RhoC-ROCK1 Signaling Pathway. DNA Methylation and BMI: Investigating Identified Methylation Sites at HIF3A in a Causal Framework.

2006年6月15日 · HIF-3α was strongly induced by hypoxia (1% O 2) both at the level of protein and mRNA due to an increase in protein stability and transcriptional activation, whereas HIF-1α protein and mRNA levels...