2024年12月25日 · HAPLN1 (Hyaluronan And Proteoglycan Link Protein 1) is a Protein Coding gene. Diseases associated with HAPLN1 include Juvenile Rheumatoid Arthritis and Cerebral Creatine Deficiency Syndrome 1. Among its related pathways are …

Hyaluronan and proteoglycan link protein 1 is a protein that in humans is encoded by the HAPLN1 gene. [5] [6] [7]

2023年4月24日 · Extracellular HAPLN1 modifies cancer cells and fibroblasts, rendering them more immunomodulatory. As such, we identify HAPLN1 as a prognostic marker and as a driver for peritoneal metastasis in...

2024年3月12日 · Here we show that HAPLN1 in the dermal ECM is sufficient to maintain the integrity of melanoma-associated blood vessels, as indicated by increased collagen and VE-cadherin expression.

2022年6月2日 · HAPLN1 maintains aggregation and the binding activity of extracellular matrix (ECM) molecules (such as hyaluronic acid and proteoglycan) to stabilize the macromolecular structure of the ECM.

In this current study, we identified a BMSC-secreted factor, hyaluronan and proteoglycan link protein 1 (HAPLN1), that can induce bortezomib-resistant NF-κB activity in MM cells. Specifically, HAPLN1 proteoglycan tandem repeat (PTR) domain 1 and 2 fragments have strong PIR NF-κB–inducing activities.

2024年9月11日 · HAPLN1 is a structural protein that links HA and proteoglycans, thus promoting the formation of stable water-rich aggregates in the pericellular matrix (PCM). Our studies suggest that HAPLN1 is a key player that reduces or eliminates cellular damage accumulated in aging skin owing to its involvement in multiple regeneration mechanisms, such as ...