2024年12月25日 · HADH (Hydroxyacyl-CoA Dehydrogenase) is a Protein Coding gene. Diseases associated with HADH include Hyperinsulinemic Hypoglycemia, Familial, 4 and 3-Hydroxyacyl-Coa Dehydrogenase Deficiency. Among its related pathways are Mitochondrial Fatty Acid Beta-Oxidation and Fatty acid metabolism.

Hydroxyacyl-Coenzyme A dehydrogenase (HADH) is an enzyme which in humans is encoded by the HADH gene. [5][6] The HADH gene is located on the 4th chromosome, with its specific location being identified as 4q22-q26. The gene has 10 exons. [7] . The HADH gene encodes a 34.3 kDa protein that has 314 amino acids and 124 observed peptides. [8][9]

The HADH gene provides instructions for making an enzyme called 3-hydroxyacyl-CoA dehydrogenase that is important for converting certain fats to energy. Learn about this gene and related health conditions.

HADH gene mutations can lead either to severe neonatal HH or to mild, late (even adult) onset, protein-induced HH (66,67). Mutations of HADH gene have been reported as one of the most common cause of diazoxide responsive CHI in consanguineous pedigrees.

2025年1月4日 · Title: Abnormal expression of HADH, an enzyme of fatty acid oxidation, affects tumor development and prognosis (Review). Differentially expressed genes PCCA, ECHS1, and HADH are potential prognostic biomarkers for gastric cancer.

The gene of HADH is an essential gene of fatty acid oxidation, which seems to be a survival strategy for tumor cells in an anoxic environment . It is hypothesized that the interaction between the gene of HADH and HIF might be the potential mechanism regulating fatty acid oxidation.

The HADH gene provides instructions for making an enzyme called 3-hydroxyacyl-CoA dehydrogenase. Normally, through a process called fatty acid oxidation, several enzymes work in a step-wise fashion to break down (metabolize) fats and convert them to energy.

Hyperinsulinism due to short chain 3-hydroxylacyl-CoA dehydrogenase deficiency is a genetic condition that prevents the body from converting certain fats into energy. This causes sensitivity to insulin and hypoglycemia (low blood sugar levels).

2024年12月10日 · This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway.

Abnormal expression of HADH, an enzyme of fatty acid oxidation, affects tumor development and prognosis (Review). Differentially expressed genes PCCA, ECHS1, and HADH are potential prognostic biomarkers for gastric cancer.