Heat shock protein 47 has been shown to interact with collagens I, II, III, IV and V. [9] It is involved in the secretion of collagen as well as the processing, assembly, and folding of collagen proteins. Hsp 47 binds specifically to procollagen and collagen only.

Expert opinion: As a collagen-specific chaperon, HSP47 is a promising therapeutic target in fibrosis. Preclinical models have shown encouraging anti-fibrotic results. Anti-HSP47 strategies need to be further evaluated in clinical trials.

2016年11月14日 · Hsp47识别三螺旋原胶原蛋白上的胶原蛋白（Gly-Xaa-Arg）重复序列，可以防止原胶原蛋白的局部展开和/或聚集。 小鼠Hsp47的基因破坏由于基底膜受损和胶原原纤维形成而导致胚胎致死率。

Hsp47 is a heat-shock protein that interacts transiently with procollagen during its folding, assembly and transport from the endoplasmic reticulum (ER) of mammalian cells. It has been suggested to carry out a diverse range of functions, such as ...

2023年11月11日 · Here, the authors identify HSP47 as a pivotal determinant of body adiposity which is abundantly expressed in fat tissue and influenced by factors such as diet, exercise, hormones, and genetics.

Gene ablation studies indicated that Hsp47 is essential for embryonic development and the maturation of several types of collagen. The requirement for Hsp47 in collagen maturation may reflect its ability to inhibit collagen aggregation by binding procollagen in …

Hsp47, a collagen-specific molecular chaperone that localizes in the endoplasmic reticulum (ER), is indispensable for molecular maturation of collagen. Hsp47, which is encoded by the SERPINH1 gene, belongs to the serpin family and has the serpin fold; however, it …

2018年12月12日 · Heat shock protein 47 (Hsp47) is an endoplasmic reticulum (ER)-resident molecular chaperone essential for correct folding of procollagen in mammalian cells. In this Review, we discuss the role and function of Hsp47 in vertebrate cells and its role in connective tissue disorders.

hsp47 是一种胶原蛋白特异性伴侣，在胶原蛋白折叠中起关键作用。 本综述讨论了 HSP47 的抗纤维化潜力。 涵盖的领域：该评论汇编了从 01/2005 到 06/2020 从 PubMed 数据库中检索到的数据，关键字为“HSP47+纤维化”。

Heat shock protein 47 (Hsp47) is a procollagen/collagen-specific molecular chaperone protein derived from the serpin family of proteins and essential for the early stages of collagen biosynthesis.