HNF4 (Hepatocyte Nuclear Factor 4) is a nuclear receptor protein mostly expressed in the liver, gut, kidney, and pancreatic beta cells that is critical for liver development. In humans, there are two paralogs of HNF4, HNF4α and HNF4γ, encoded by …

Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (nuclear receptor subfamily 2, group A, member 1) is a nuclear receptor that in humans is encoded by the HNF4A gene. [5][6] HNF-4α is a nuclear transcription factor that binds DNA as a homodimer.

Hepatocyte nuclear factor 4 (HNF4) family are transcription factors that bind fatty acids. We investigated how HNF4 transcription factors regulate metabolism and their functions in ISCs in mice. Methods: We performed studies with Villin-Cre ERT2;Lgr5-EGFP-IRES-Cre ERT2;Hnf4α f/f;Hnf4γ Crispr/Crispr mice, hereafter referred to Hnf4αγ DKO ...

HNF4α在转录水平上调控肝脏特异基因的表达,促进肝细胞的发育和分化,参与肝细胞极性的建立和维持,增强肝脏的合成、代谢以及解毒功能。 HNF4α可通过抑制肝星状细胞的活化、逆转上皮间质细胞转化、抑制肝癌细胞增殖、侵袭和转移等机制,参与肝纤维化、肝硬化、肝细胞癌等疾病的发生和变化过程。 阐述了HNF4α的生物学功能,对其参与多种主要肝脏疾病信号通路机制的研究进展进行了分析总结,旨在为进一步发掘这一潜在的肝脏疾病靶向治疗途径提供参考。

2021年1月18日 · Hepatocyte nuclear factor 4α (HNF4α), a member of the nuclear receptor superfamily, is described as a protein that binds to the promoters of specific genes....

2023年12月31日 · Hepatocyte nuclear factor 4a (HNF4α), a member of nuclear receptor superfamily, functions as a nuclear transcription factor by forming homodimers that effectively bind to DNA [1]. HNF4α is a critical regulator extends across various domains including liver and kidney development, intestinal function, as well as in lipid and glucose metabolism [2].

Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs (pancreas, stomach, and intestine).

肝细胞核因子4α (HNF4α)是核受体超家族的一员，调控多种肝脏特异性基因的表达，在肝脏的生长、发育和代谢过程中起着非常重要的作用。 近年研究发现，HNF4α在各种肝脏疾病中均存在表达变化，在肝脏疾病的发生、发展过程中处于转录调控网络的中心节点，上调HNF4α表达可显著缓解慢性肝病进程并抑制甚至逆转肝脏肿瘤的进展。 本文对HNF4α在肝脏疾病中的作用及其调控机制进行了总结。 引用本文: 徐搏男, 张新, 谢渭芬. 肝细胞核因子4α在肝脏疾病中的作用及调控机制 [J] …

Hepatocyte Nuclear Factor 4 alpha (HNF4α) is critical for hepatic differentiation. Recent studies have highlighted its role in inhibition of hepatocyte proliferation and tumor suppression. However, the role of HNF4α in liver regeneration is not known.

2023年6月19日 · Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor (NR) family that is expressed in liver, kidney, intestine and pancreas. It is a master regulator of liver-specific gene expression, in particular those genes involved in lipid transport and glucose me …