HMOX1 (heme oxygenase 1 gene) is a human gene that encodes for the enzyme heme oxygenase 1 (EC 1.14.99.3). Heme oxygenase (abbreviated HMOX or HO) mediates the first step of heme catabolism, it cleaves heme to form biliverdin.

2024年12月25日 · HMOX1 (Heme Oxygenase 1) is a Protein Coding gene. Diseases associated with HMOX1 include Heme Oxygenase 1 Deficiency and Pulmonary Disease, Chronic Obstructive. Among its related pathways are Nuclear events mediated by NFE2L2 and Inflammasomes.

H eme oxygenases (HMOX) are rate-limiting enzymes that degrade heme (iron protoporphyrin IX) to carbon monoxide (CO), ferrous iron (Fe 2+), and biliverdin IXα. Biliverdin IXα is, subsequently, converted to bilirubin IXα by biliverdin reductase (BVR).

2021年11月1日 · We demonstrated that HMOX1 upregulation is responsible for the increased ferroptosis in diabetic atherosclerosis development, suggesting that HMOX1 may serve as a potential therapeutic or drug development target for diabetic atherosclerosis.

Hmox1 − /− mice were sensitized to tissue injury in a murine hindlimb ischemia model. Tissue protection associated with HO-1 was attributed to downstream modulation of Hif-1α, which coordinates adaptive responses to hypoxia.

2025年2月8日 · Title: HMOX1 as a therapeutic target associated with diabetic foot ulcers based on single-cell analysis and machine learning. The study of HMOX1 DNA methylation and gene expression and the diagnostic potential of miR-153-3p in preeclampsia.

2025年1月27日 · Heme oxygenase 1 (HMOX1) regulates oxidative stress, but its role in airway diseases needs exploration. Methods: Differentially expressed genes (DEGs) between healthy nasal mucosa and chronic rhinosinusitis with nasal polyps (CRSwNP) were identified from Gene Expression Omnibus (GEO).

Objective: Hmox1 (heme oxygenase-1) is a stress-induced enzyme that catalyzes the degradation of heme to carbon monoxide, iron, and biliverdin. Induction of Hmox1 and its products protect against cardiovascular disease, including ischemic injury.

HMOX1 Promotes Ferroptosis Induced by Erastin in Lens Epithelial Cell through Modulates Fe[2+] Production. Dynamics of antioxidant heme oxygenase-1 and pro-oxidant p66Shc in promoting advanced prostate cancer progression.

HO-1 is encoded by the HMOX1 gene and is regulated mainly at the transcriptional level (Ryter, 2022). The promoter region of the HMOX1 gene contains multiple antioxidant response elements (AREs) that are recognized by stress-responsive factors (Zhou et al., 2021).